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. 2002 Jan;40(1):10-5.
doi: 10.1128/JCM.40.1.10-15.2002.

Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000

Jen-Ren Wang  1 , Yen-Chang Tuan, Huey-Pin Tsai, Jing-Jou Yan, Ching-Chuan Liu, Ih-Jen Su
Affiliations

Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000

Jen-Ren Wang et al. J Clin Microbiol. 2002 Jan.

Abstract

Two outbreaks of hand-foot-and-mouth disease (HFMD) occurred in Taiwan between 1998 and 2000. Enteroviruses were isolated from a total of 1,892 patients in this laboratory during this period. Of the virus isolates, enterovirus 71 (EV71) was diagnosed in 44.4% of the patients (132 of 297) in 1998, 2% (13 of 646) in 1999, and 20.5% (195 of 949) in 2000. Genetic analyses of the 5'-untranslated and VP1 regions of EV71 isolates by reverse transcription-PCR and sequencing were performed to understand the diversity of EV71 in these outbreaks of HFMD. Most EV71 isolates from the 1998 epidemic belonged to genotype C, while only one-tenth of the isolates were genotype B. Interestingly, all EV71 isolates tested from 1999 to 2000 belonged to genotype B. This study indicated that two genogroups of EV71 capable of inducing severe clinical illness have been circulating in Taiwan. Furthermore, the predominant EV71 genotypes responsible for each of the two major HFMD outbreaks within the 3-year period in Taiwan were different.

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Figures

FIG. 1.
FIG. 1.
Dendrogram of the 48 outbreak strains, four reference strains from GenBank, and one isolate from 1986, based on 648 nt (nt 98 to 745) of the 5′-UTR gene using the neighbor-joining method with the DNADIST distance measure program (PHYLIP, version 3.573c). The percentage of bootstrap frequency of each branch in tree is indicated. CA16 was included as an outgroup.
FIG. 2.
FIG. 2.
Dendrogram of the 28 outbreak strains and five reference strains from GenBank, based on 841 nt (nt 2439 to 3280) of the VP1 gene. The branch length for the outgroup, CA16-G10-51, was reduced by 0.5 in the dendrogram.
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