Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine
- PMID: 11756990
- DOI: 10.1086/338014
Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine
Abstract
Influenza remains a major cause of morbidity and mortality, particularly in at-risk groups where vaccination reduces complications of infection but is not universally protective. In order to determine whether human leukocyte antigen (HLA) class II polymorphisms modulate anti-influenza antibody responses to vaccination, a cohort of HLA-typed at-risk donors was investigated. The subjects were recruited from a single urban family practice. Hemagglutination-inhibition (HAI) titers were measured immediately before and 28 days after subunit vaccination. Nonresponsiveness was defined as failure to mount an HAI response to any component of the trivalent influenza vaccine. When the nonresponders and responders with HLA class II were compared, the nonresponder group had more HLA-DRB1*07-positive donors (13/32 vs. 6/41 responders; P=.016, Fisher's exact test) and fewer HLA-DQB1*0603-9/14-positive donors (2/32 vs. 14/41 responders; P=.0045). Thus, polymorphisms in HLA class II molecules appear to modulate antibody responses to influenza vaccination.
Similar articles
-
Immunogenetics of seasonal influenza vaccine response.Vaccine. 2008 Sep 12;26 Suppl 4(Suppl 4):D35-40. doi: 10.1016/j.vaccine.2008.07.065. Vaccine. 2008. PMID: 19230157 Free PMC article. Review.
-
Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?Pediatrics. 2006 Sep;118(3):e570-8. doi: 10.1542/peds.2006-0198. Pediatrics. 2006. PMID: 16950948 Clinical Trial.
-
The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients.Scand J Urol Nephrol. 2003;37(1):71-6. doi: 10.1080/00365590310008749. Scand J Urol Nephrol. 2003. PMID: 12745749
-
Immune responses to killed influenza vaccine in patients with type 1 diabetes: altered responses associated with HLA-DR 3 and DR 4.J Lab Clin Med. 1988 Nov;112(5):595-602. J Lab Clin Med. 1988. PMID: 3263455
-
Human genetics and responses to influenza vaccination: clinical implications.Am J Pharmacogenomics. 2004;4(5):293-8. doi: 10.2165/00129785-200404050-00002. Am J Pharmacogenomics. 2004. PMID: 15462607 Review.
Cited by
-
Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly.BMC Infect Dis. 2019 Jul 23;19(1):656. doi: 10.1186/s12879-019-4214-x. BMC Infect Dis. 2019. PMID: 31337344 Free PMC article.
-
Factors That Influence the Immune Response to Vaccination.Clin Microbiol Rev. 2019 Mar 13;32(2):e00084-18. doi: 10.1128/CMR.00084-18. Print 2019 Mar 20. Clin Microbiol Rev. 2019. PMID: 30867162 Free PMC article. Review.
-
Immunogenetics of seasonal influenza vaccine response.Vaccine. 2008 Sep 12;26 Suppl 4(Suppl 4):D35-40. doi: 10.1016/j.vaccine.2008.07.065. Vaccine. 2008. PMID: 19230157 Free PMC article. Review.
-
Genetic determinants of immune-response to a polysaccharide vaccine for typhoid.Hugo J. 2009 Dec;3(1-4):17-30. doi: 10.1007/s11568-010-9134-1. Epub 2010 Mar 11. Hugo J. 2009. PMID: 21119757 Free PMC article.
-
Rapid whole-blood assay to detect SARS-CoV-2-specific memory T-cell immunity following a single dose of AstraZeneca ChAdOx1-S COVID-19 vaccine.Clin Transl Immunology. 2021 Aug 12;10(8):e1326. doi: 10.1002/cti2.1326. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34408875 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
