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Review
. 2001 Dec;108(12):1729-33.
doi: 10.1172/JCI14660.

gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways

E Arzt  1
Affiliations
Review

gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways

E Arzt. J Clin Invest. 2001 Dec.
No abstract available

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Figures

Figure 1
Figure 1
Schematic model of the IL-6/gp130 receptor system. The specific cytokine-binding subunits and gp130 belong to a cytokine receptor superfamily characterized by four positionally conserved cysteine residues and a WSXWS motif. Functional receptor complexes are induced by the different gp130 cytokines: IL-6 and IL-11 induce gp130 homodimerization; CNTF, LIF, CT-1, and OSM induce LIFRα/gp130 heterodimers; and OSM may also induce OSMRα/gp130 heterodimers. Following ligand binding, gp130 is responsible for signal transduction through the JAK/STAT pathways.
Figure 2
Figure 2
gp130 cytokine family pathways on anterior pituitary cells. Following immune (e.g., LPS) or hormonal (e.g., PACAP) stimulation, systemic or anterior pituitary gp130 cytokines, expressed by FS cells among others, induce the stimulation of ACTH (detailed in the scheme) in the pituitary. In this pathway, which is distinct from another mechanism activated by CRH or IL-1, POMC expression and ACTH secretion are stimulated through STAT3, providing a new powerful mechanism for regulation of corticotroph function.
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