doi: 10.1038/414813a.
Biochemistry and molecular cell biology of diabetic complications
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- PMID: 11742414
- DOI: 10.1038/414813a
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Biochemistry and molecular cell biology of diabetic complications
Nature.
.
Abstract
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
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