Nuclear receptors and lipid physiology: opening the X-files
- PMID: 11729302
- DOI: 10.1126/science.294.5548.1866
Nuclear receptors and lipid physiology: opening the X-files
Abstract
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed by the intestine and transformed by metabolic enzymes before they are delivered to their sites of action in the body. Ultimately, the lipids must be eliminated to maintain a normal physiological state. The need to coordinate this entire lipid-based metabolic signaling cascade raises important questions regarding the mechanisms that govern these pathways. Specifically, what is the nature of communication between these bioactive lipids and their receptors, binding proteins, transporters, and metabolizing enzymes that links them physiologically and speaks to a higher level of metabolic control? Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
Similar articles
-
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.Arch Biochem Biophys. 2005 Jan 15;433(2):387-96. doi: 10.1016/j.abb.2004.08.030. Arch Biochem Biophys. 2005. PMID: 15581595 Review.
-
[Heterodimeric nuclear receptors. II. Fatty acid and steroid metabolism regulation].Postepy Biochem. 2000;46(2):125-9. Postepy Biochem. 2000. PMID: 11058998 Review. Polish. No abstract available.
-
[Nuclear receptor regulation of cholesterol metabolism].Nihon Rinsho. 2001 Feb;59 Suppl 2:468-71. Nihon Rinsho. 2001. PMID: 11351632 Japanese. No abstract available.
-
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.J Biol Chem. 2001 Oct 12;276(41):37735-8. doi: 10.1074/jbc.R100035200. Epub 2001 Jul 17. J Biol Chem. 2001. PMID: 11459853 Review. No abstract available.
-
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.Recent Prog Horm Res. 1999;54:345-67; discussion 367-8. Recent Prog Horm Res. 1999. PMID: 10548883 Review.
Cited by
-
Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential.Front Pharmacol. 2024 Oct 16;15:1464655. doi: 10.3389/fphar.2024.1464655. eCollection 2024. Front Pharmacol. 2024. PMID: 39478961 Free PMC article. Review.
-
Design and synthesis of boron containing potential pan-RAR inverse agonists.Tetrahedron Lett. 2012 Mar 14;53(11):1316-1318. doi: 10.1016/j.tetlet.2011.12.118. Epub 2012 Jan 3. Tetrahedron Lett. 2012. PMID: 23180890 Free PMC article.
-
Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes.PLoS One. 2012;7(11):e48738. doi: 10.1371/journal.pone.0048738. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185273 Free PMC article.
-
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.J Nutr Biochem. 2013 May;24(5):754-9. doi: 10.1016/j.jnutbio.2012.04.002. Epub 2012 Jul 25. J Nutr Biochem. 2013. PMID: 22841393 Free PMC article.
-
Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein.ACS Chem Neurosci. 2013 Jul 17;4(7):1093-100. doi: 10.1021/cn400039s. Epub 2013 Apr 15. ACS Chem Neurosci. 2013. PMID: 23530929 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
