Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Dec;11(6):627-34.
doi: 10.1016/s0959-437x(00)00245-8.

Genome-wide variation in the human and fruitfly: a comparison

C F Aquadro  1 , V Bauer DuMont, F A Reed
Affiliations
Review

Genome-wide variation in the human and fruitfly: a comparison

C F Aquadro et al. Curr Opin Genet Dev. 2001 Dec.

Abstract

Average levels of nucleotide diversity are ten-fold lower in humans than in the fruitfly, Drosophila melanogaster. Despite this difference, apparently as a result of a lower population size, patterns of genomic diversity are strikingly similar in being correlated with local rates of recombination, and influenced by similar interactions between positive natural selection and recombination. Both species also show lower levels of variation on average in non-African compared to African populations, reflecting a similar evolutionary history and perhaps both natural selection and founder effects in new environments.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Selection of Phototransduction Genes in Homo sapiens.
    Christopher M, Scheetz TE, Mullins RF, Abràmoff MD. Christopher M, et al. Invest Ophthalmol Vis Sci. 2013 Aug 13;54(8):5489-96. doi: 10.1167/iovs.12-11454. Invest Ophthalmol Vis Sci. 2013. PMID: 23868983 Free PMC article.
  • Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes.
    Reed FA, Akey JM, Aquadro CF. Reed FA, et al. Genome Res. 2005 Sep;15(9):1211-21. doi: 10.1101/gr.3413205. Genome Res. 2005. PMID: 16140989 Free PMC article.
  • Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.
    Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK; Nasonia Genome Working Group; Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK, Beukeboom LW, Desplan C, Elsik CG, Grimmelikhuijzen CJ, Kitts P, Lynch JA, Murphy T, Oliveira DC, Smith CD, van de Zande L, Worley KC, Zdobnov EM, Aerts M, Albert S, Anaya VH, Anzola JM, Barchuk AR, Behura SK, Bera AN, Berenbaum MR, Bertossa RC, Bitondi MM, Bordenstein SR, Bork P, Bornberg-Bauer E, Brunain M, Cazzamali G, Chaboub L, Chacko J, Chavez D, Childers CP, Choi JH, Clark ME, Claudianos C, Clinton RA, Cree AG, Cristino AS, Dang PM, Darby AC, de Graaf DC, Devreese B, Dinh HH, Edwards R, Elango N, Elhaik E, Ermolaeva O, Evans JD, Foret S, Fowler GR, Gerlach D, Gibson JD, Gilbert DG, Graur D, Gründer S, Hagen DE, Han Y, Hauser F, Hultmark D, Hunter HC 4th, Hurst GD, Jhangian SN, Jiang H, Johnson RM, Jones AK, Junier T, Kadowaki T, Kamping A, Kapustin Y, Kechavarzi B, Kim J, Kim J, Kiryutin B, Koevoets T, Kovar CL, Kriventseva EV, Kucharski R, Lee H, Lee SL, Lees K, Lewis LR, Loehlin DW, Logsdon JM Jr, Lopez JA, Lozado RJ, Maglott D, Maleszka R, Mayampurath A, Mazur DJ, McClure MA, Moore AD, Morgan MB, Mul… See abstract for full author list ➔ Werren JH, et al. Science. 2010 Jan 15;327(5963):343-8. doi: 10.1126/science.1178028. Science. 2010. PMID: 20075255 Free PMC article.
  • Genomic hotspots for adaptation: the population genetics of Müllerian mimicry in Heliconius erato.
    Counterman BA, Araujo-Perez F, Hines HM, Baxter SW, Morrison CM, Lindstrom DP, Papa R, Ferguson L, Joron M, Ffrench-Constant RH, Smith CP, Nielsen DM, Chen R, Jiggins CD, Reed RD, Halder G, Mallet J, McMillan WO. Counterman BA, et al. PLoS Genet. 2010 Feb 5;6(2):e1000796. doi: 10.1371/journal.pgen.1000796. PLoS Genet. 2010. PMID: 20140239 Free PMC article.
  • Nucleotide variation of the Est-6 gene region in natural populations of Drosophila melanogaster.
    Balakirev ES, Ayala FJ. Balakirev ES, et al. Genetics. 2003 Dec;165(4):1901-14. doi: 10.1093/genetics/165.4.1901. Genetics. 2003. PMID: 14704175 Free PMC article.
See all "Cited by" articles

LinkOut - more resources