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. 1975 Jun;147(3):523-9.
doi: 10.1042/bj1470523.

Chemical and metabolic properties of adenosine diphosphate ribose derivatives of nuclear proteins

J A Smith, L A Stocken

Chemical and metabolic properties of adenosine diphosphate ribose derivatives of nuclear proteins

J A Smith et al. Biochem J. 1975 Jun.

Abstract

1. ADP-ribose is found in rat liver nuclei covalently bound to histone F1, to a non-histone protein, and to a small peptide. 2. A single unit of ADP-ribose, covalently bound to phosphoserine, was isolated from an enzymic hydrolysate of histone F1. ADP-ribose-bearing peptides were isolated from a tryptic digest of the histone. 3. It is proposed that the 1'-hydroxyl group of ADP-ribose is linked to the phosphate group of phosphoserine in histone F1. 4. The incorporation of 32P into ADP-ribose on histone F1 a parallels the DNA content through the cell cycle. An increased incorporation of the nucleotide into the other derivatives is observed during S phase. 5. It is suggested that the ADP-ribose derivative of histone F1 has a role in maintaining the G0 state and that one or both of the other derivatives is concerned with control of DNA synthesis.

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