Role of microvilli in surface changes of synchronized P815Y mastocytoma cells
- PMID: 1158972
- PMCID: PMC2109462
- DOI: 10.1083/jcb.66.3.568
Role of microvilli in surface changes of synchronized P815Y mastocytoma cells
Abstract
The surface morphology of synchronized P815Y mastocytoma cells has been examined by scanning electron microscopy. Early G1 cells are comparatively smooth or light villated, whereas at later stages the surface becomes progressively more villated. In G1 cell most microvilli have a uniform diameter, whereas in S and G2 cells, many microvilli show branching and often originate from much larger surface protuberances. Small "blebs" are seen on the surface of many cells but these structures do not appear to be a characteristic feature of cells at any one stage of the cycle. The presence of microvilli increases the total surface of the cell to such an extent that the ratio of volume to surface area remains constant throughout the cell cycle. The mechanism of cytokinesis is thus a physical one, involving the unfolding of previously accumulated microvilli.
Similar articles
-
Cell surface changes during mitosis and cytokinesis of epithelial cells.Cell Tissue Res. 1984;237(3):409-17. doi: 10.1007/BF00228425. Cell Tissue Res. 1984. PMID: 6488284
-
Studies on corneal endothelial growth and repair. IV. Changes in the surface during cell division as revealed by scanning electron microscopy.Eur J Cell Biol. 1983 Jul;31(1):26-33. Eur J Cell Biol. 1983. PMID: 6604630
-
Alteration in the surface morphology of synchronized B-16 melanoma cell during the cell cycle.Acta Derm Venereol. 1975;55(5):331-6. Acta Derm Venereol. 1975. PMID: 52966
-
Structural changes in the plasma membrane of synchronized P815Y mastocytoma cells.Exp Cell Res. 1976 Oct 1;102(1):109-16. doi: 10.1016/0014-4827(76)90305-0. Exp Cell Res. 1976. PMID: 976336 No abstract available.
-
A membrane reservoir at the cell surface: unfolding the plasma membrane to fuel cell shape change.Bioarchitecture. 2014 Mar-Apr;4(2):39-46. doi: 10.4161/bioa.29069. Epub 2014 May 20. Bioarchitecture. 2014. PMID: 24844289 Free PMC article. Review.
Cited by
-
Spectrin redistributes to the cytosol and is phosphorylated during mitosis in cultured cells.J Cell Biol. 1992 Dec;119(6):1559-72. doi: 10.1083/jcb.119.6.1559. J Cell Biol. 1992. PMID: 1469048 Free PMC article.
-
TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila.J Cell Sci. 2009 Dec 15;122(Pt 24):4526-34. doi: 10.1242/jcs.054536. Epub 2009 Nov 24. J Cell Sci. 2009. PMID: 19934220 Free PMC article.
-
Regulation of the Total Cell Surface Area in Dividing Dictyostelium Cells.Front Cell Dev Biol. 2020 Apr 8;8:238. doi: 10.3389/fcell.2020.00238. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32322581 Free PMC article.
-
The electrophoretic properties and aggregation of mouse lymphoma cells, chinese-hamster fibroblasts and a somatic-cell hybrid.Biochem J. 1976 Nov 15;160(2):325-34. doi: 10.1042/bj1600325. Biochem J. 1976. PMID: 12752 Free PMC article.
-
De novo lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion. Implications for combined chemotherapy.Cell Cycle. 2019 Jul;18(14):1646-1659. doi: 10.1080/15384101.2019.1629792. Epub 2019 Jun 15. Cell Cycle. 2019. PMID: 31203714 Free PMC article.
