Phosphatidylserine, a death knell
- PMID: 11536005
- DOI: 10.1038/sj.cdd.4400817
Phosphatidylserine, a death knell
Abstract
Virtually every cell in the body restricts phosphatidylserine (PS) to the inner leaflet of the plasma membrane by energy-dependent transport from the outer to the inner leaflet of the bilayer. Apoptotic cells of all types rapidly randomize the asymmetric distribution, bringing PS to the surface where it serves as a signal for phagocytosis. A myriad of phagocyte receptors have been implicated in the recognition of apoptotic cells, among them a PS receptor, yet few ligands other than PS have been identified on the apoptotic cell surface. Since apoptosis and the associated exposure of PS on the cell surface is probably over 600 million years old, it is not surprising that evolution has appropriated aspects of this process for specialized purposes such as blood coagulation, membrane fusion and erythrocyte differentiation. Failure to efficiently remove apoptotic cells may contribute to inflammatory responses and autoimmune diseases resulting from chronic, inappropriate exposure of PS.
Comment in
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Engulfing by lipids: a matter of taste?Cell Death Differ. 2001 Jun;8(6):545-8. doi: 10.1038/sj.cdd.4400833. Cell Death Differ. 2001. PMID: 11536003 No abstract available.
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