Review
doi: 10.1038/35089575.
Re-evaluating centrosome function
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- PMID: 11533726
- DOI: 10.1038/35089575
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Review
Re-evaluating centrosome function
Nat Rev Mol Cell Biol.
2001 Sep.
Abstract
Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.
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