Cisplatin: from DNA damage to cancer chemotherapy
- PMID: 11525387
- DOI: 10.1016/s0079-6603(01)67026-0
Cisplatin: from DNA damage to cancer chemotherapy
Abstract
Cisplatin [cis-DDP, cis-diamminedichloroplatinum(II)] is a potent anticancer drug that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary tract. The biological activity of cisplatin was discovered serendipitously more than 30 years ago, and since that time research efforts have focused on elucidating its mechanism of action. The present review provides a historical perspective of our attempts to understand this complex phenomenon and the results of recent work that guides our current activities in this field. Continued efforts to understand the mechanism of genotoxicity of cisplatin are expected to lead to the discovery of new drugs and combinations for the improvement of cancer chemotherapy.
Similar articles
-
Proteins that bind to and mediate the biological activity of platinum anticancer drug-DNA adducts.Met Ions Biol Syst. 1996;32:687-726. Met Ions Biol Syst. 1996. PMID: 8640535 Review. No abstract available.
-
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.Nature. 1999 Jun 17;399(6737):708-12. doi: 10.1038/21460. Nature. 1999. PMID: 10385126
-
The major chromatin protein histone H1 binds preferentially to cis-platinum-damaged DNA.Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13448-51. doi: 10.1073/pnas.94.25.13448. Proc Natl Acad Sci U S A. 1997. PMID: 9391045 Free PMC article.
-
Interaction between cisplatin-modified DNA and the HMG boxes of HMG 1: DNase I footprinting and circular dichroism.J Mol Biol. 1995 Feb 17;246(2):243-7. doi: 10.1006/jmbi.1994.0079. J Mol Biol. 1995. PMID: 7869375
-
Recognition of cisplatin adducts by cellular proteins.Mutat Res. 2001 Jul 1;478(1-2):1-21. doi: 10.1016/s0027-5107(01)00142-7. Mutat Res. 2001. PMID: 11406166 Review.
Cited by
-
Horizontal Transfer of miR-643 from Cisplatin-Resistant Cells Confers Chemoresistance to Recipient Drug-Sensitive Cells by Targeting APOL6.Cells. 2021 May 28;10(6):1341. doi: 10.3390/cells10061341. Cells. 2021. PMID: 34071504 Free PMC article.
-
An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy.Antioxidants (Basel). 2022 Sep 7;11(9):1762. doi: 10.3390/antiox11091762. Antioxidants (Basel). 2022. PMID: 36139836 Free PMC article.
-
Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations.Br J Cancer. 2006 Nov 20;95(10):1348-53. doi: 10.1038/sj.bjc.6603434. Epub 2006 Oct 24. Br J Cancer. 2006. PMID: 17060935 Free PMC article.
-
Integrin α5 promotes migration and cisplatin resistance in esophageal squamous cell carcinoma cells.Am J Cancer Res. 2019 Dec 1;9(12):2774-2788. eCollection 2019. Am J Cancer Res. 2019. PMID: 31911861 Free PMC article.
-
Pharmacological activation of NQO1 increases NAD⁺ levels and attenuates cisplatin-mediated acute kidney injury in mice.Kidney Int. 2014 Mar;85(3):547-60. doi: 10.1038/ki.2013.330. Epub 2013 Sep 11. Kidney Int. 2014. PMID: 24025646 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources