Adenoid cystic carcinoma of the head and neck
- PMID: 11513507
- DOI: 10.1054/bjps.2001.3636
Adenoid cystic carcinoma of the head and neck
Abstract
Adenoid cystic carcinoma (ACC) is a rare malignant tumour believed to arise from the epithelial cells of mucous-secreting glands. It is a slow-growing but aggressive tumour with a propensity for perineural invasion. A 10 year review of 45 patients (19 males and 26 females with a median age of 56 years) treated for ACC at a single institution between 1989 and 1999 was performed to analyse factors involved in treatment failure, local control, treatment-related morbidity and mortality. The data collected were treated for survival curves according to the Kaplan-Meier method and the log-rank test was used to assess the statistical significance of the various groups. The overall survivals at 3 years and 5 years were 71% and 65%, respectively, while the disease-free survivals at 3 years and 5 years were 73% and 63% respectively. Out of the 45 patients, only six had local recurrences, yielding an 87% locoregional freedom from relapse; 16 patients (35.6%) developed distant metastases, with the lung (8/16) being the commonest site. Patients treated for tumours of the nose and paranasal sinuses experienced more morbidity than those with tumours at other sites. Positive margins, perineural invasion and solid histology of ACC were associated with increased morbidity and treatment failure. Patients treated with combined therapy did better than those who underwent a single treatment modality.
Copyright 2001 The British Association of Plastic Surgeons.
Similar articles
-
[Adenoid cystic carcinoma of the head and neck: a review of 30 cases].Rev Laryngol Otol Rhinol (Bord). 2003;124(4):235-41. Rev Laryngol Otol Rhinol (Bord). 2003. PMID: 15038566 French.
-
Management of adenoid cystic carcinoma of minor salivary glands.J Oral Maxillofac Surg. 2006 Jul;64(7):1114-20. doi: 10.1016/j.joms.2005.06.017. J Oral Maxillofac Surg. 2006. PMID: 16781345
-
Lung metastasis resection of adenoid cystic carcinoma of salivary glands.Eur J Cardiothorac Surg. 2008 May;33(5):790-3. doi: 10.1016/j.ejcts.2007.12.057. Epub 2008 Mar 14. Eur J Cardiothorac Surg. 2008. PMID: 18343149
-
Adenoid cystic carcinoma of the head and neck--a 20 years experience.Int J Oral Maxillofac Surg. 2004 Jan;33(1):25-31. doi: 10.1054/ijom.2003.0448. Int J Oral Maxillofac Surg. 2004. PMID: 14690656 Review.
-
Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature.Oral Oncol. 2005 Mar;41(3):328-35. doi: 10.1016/j.oraloncology.2004.12.004. Oral Oncol. 2005. PMID: 15743696 Review.
Cited by
-
Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series.Sao Paulo Med J. 2006 Jan 5;124(1):26-30. doi: 10.1590/s1516-31802006000100006. Epub 2006 Apr 3. Sao Paulo Med J. 2006. PMID: 16612459 Free PMC article.
-
Expression of RUNX3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis.Cancer Sci. 2008 Jul;99(7):1334-40. doi: 10.1111/j.1349-7006.2008.00826.x. Epub 2008 Apr 11. Cancer Sci. 2008. PMID: 18410404 Free PMC article.
-
Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.Eur Arch Otorhinolaryngol. 2018 Dec;275(12):3039-3047. doi: 10.1007/s00405-018-5182-2. Epub 2018 Oct 26. Eur Arch Otorhinolaryngol. 2018. PMID: 30367261
-
Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial.Head Neck. 2015 May;37(5):722-6. doi: 10.1002/hed.23664. Epub 2014 Jun 18. Head Neck. 2015. PMID: 24596143 Free PMC article. Clinical Trial.
-
Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials.Head Neck. 2016 Apr;38(4):620-7. doi: 10.1002/hed.23925. Epub 2015 Jun 16. Head Neck. 2016. PMID: 25487882 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical