doi: 10.1038/90476.
CRMP-2 induces axons in cultured hippocampal neurons
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- PMID: 11477421
- DOI: 10.1038/90476
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CRMP-2 induces axons in cultured hippocampal neurons
Nat Neurosci.
2001 Aug.
Abstract
In cultured hippocampal neurons, one axon and several dendrites differentiate from a common immature process. Here we found that CRMP-2/TOAD-64/Ulip2/DRP-2 (refs. 2-4) level was higher in growing axons of cultured hippocampal neurons, that overexpression of CRMP-2 in the cells led to the formation of supernumerary axons and that expression of truncated CRMP-2 mutants suppressed the formation of primary axon in a dominant-negative manner. Thus, CRMP-2 seems to be critical in axon induction in hippocampal neurons, thereby establishing and maintaining neuronal polarity.
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