Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Jul 24;57(2):359-62.
doi: 10.1212/wnl.57.2.359.

The parkin gene is not involved in late-onset Parkinson's disease

R L Oliveri  1 , M Zappia, G Annesi, D Bosco, F Annesi, P Spadafora, A A Pasqua, C Tomaino, G Nicoletti, D Pirritano, A Labate, A Gambardella, G Logroscino, G Manobianca, A Epifanio, L Morgante, G Savettieri, A Quattrone
Affiliations

The parkin gene is not involved in late-onset Parkinson's disease

R L Oliveri et al. Neurology. .

Abstract

Mutations in the parkin gene have been reported in patients with early onset PD. The authors investigated the parkin gene in 118 patients who had an onset of PD after age 45 years: 95 subjects were sporadic patients and 23 subjects were from 18 families with a probable autosomal recessive inheritance. No pathogenetic mutations in the parkin gene were detected either in familial or in sporadic patients. Moreover, no differences were found between patients and 100 age-matched normal controls in the allele and genotype frequencies of four exonic parkin polymorphisms.

PubMed Disclaimer

Comment in

  • The parkin gene is not involved in late-onset Parkinson's disease.
    Kann M, Hedrich K, Vieregge P, Jacobs H, Müller B, Kock N, Schwinger E, Klein C, Marder K, Harris J, Meija-Santana H, Bressman S, Ozelius LJ, Lang AE, Pramstaller PP. Kann M, et al. Neurology. 2002 Mar 12;58(5):835; author reply 835. doi: 10.1212/wnl.58.5.835. Neurology. 2002. PMID: 11889262 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources