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Review
. 2001 Jul;108(2):175-80.
doi: 10.1172/JCI13561.

Heparan sulfate: lessons from knockout mice

E Forsberg  1 , L Kjellén
Affiliations
Review

Heparan sulfate: lessons from knockout mice

E Forsberg et al. J Clin Invest. 2001 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Targeting of genes important for HS expression. In the central part of the figure a cell and three different HS proteoglycans are shown. HS structure does not appear to be core protein–specific. Rather, HS chains of all proteoglycans synthesized by a certain cell have a similar structure. The HS chains contain sulfated regions (red) as well as unmodified regions (blue). The proteoglycan with its core protein embedded in the lipid bilayer belongs to the syndecan family (four members identified), while the other cell surface proteoglycan is a member of the glypican family (six members identified), attached to the cell surface via a GPI-anchor (1). The HS proteoglycan perlecan is found in the basement membrane underlying the cell (44). As shown in the figure, when genes of enzymes involved in polymerization of the HS chain are targeted (– EXT), only short stubs containing the HS linkage region will be attached to all three core proteins. Targeting of NDST genes (– NDST) results in the synthesis of unsulfated polysaccharide chains, whereas lack of any of the other modifying enzymes changes the fine structure of the HS chain (– OST; green) without altering its domain structure. Since several of the enzymes occur in isoforms, the alterations in HS structure may be more complex than shown in the figure. Targeting of a core protein (– Syndecan) will of course result in the lack of this particular proteoglycan at the cell surface.
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References

    1. Esko JD, Lindahl U. Molecular diversity of heparan sulfate. J Clin Invest. 2001;108:169–173. - PMC - PubMed
    1. Bernfield M, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999;68:729–777. - PubMed
    1. Park PW, Reizes O, Bernfield M. Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters. J Biol Chem. 2000;275:29923–29926. - PubMed
    1. Rosenberg RD, Shworak NW, Liu J, Schwartz JJ, Zhang L. Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated? J Clin Invest. 1997;100:S67–S75. - PubMed
    1. Gallagher, J.T. 2001. Heparan sulfate: growth control with a restricted sequence menu. J. Clin. Invest. In press. - PMC - PubMed

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