Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
- PMID: 11439338
- DOI: 10.1038/sj.onc.1204500
Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
Abstract
The influence of acidosis on the expression of the vascular endothelial growth factor (VEGF) gene was determined. FG human pancreatic adenocarcinoma cells were incubated for various time periods in media at a physiologically relevant pH level (6.7-7.4). The expression of VEGF mRNA and protein secretion was inversely correlated with pH in a pH- and time-dependent manner. Transient acidosis also activated the VEGF promoter/enhancer luciferase reporter, which was consistent with an increased VEGF gene transcription rate and VEGF mRNA half-life. These data indicated that acidosis transcriptionally and posttranscriptionally regulates VEGF expression, suggesting that an acidic tumor microenvironment contributes to tumor angiogenesis and progression.
Similar articles
-
Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells.Oncogene. 2002 Oct 31;21(50):7730-9. doi: 10.1038/sj.onc.1205971. Oncogene. 2002. PMID: 12400015
-
Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.Cancer Res. 2001 May 15;61(10):4143-54. Cancer Res. 2001. PMID: 11358838
-
Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells.Cancer Res. 2003 Jul 1;63(13):3495-502. Cancer Res. 2003. PMID: 12839933
-
Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.Cancer Res. 1998 Sep 1;58(17):4008-14. Cancer Res. 1998. PMID: 9731515
-
Gene therapy for coronary artery disease.Adv Card Surg. 2001;13:107-20. Adv Card Surg. 2001. PMID: 11209652 Review. No abstract available.
Cited by
-
Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution 31P MR Spectroscopic Imaging at 7.0 T.Radiol Imaging Cancer. 2024 Jan;6(1):e220127. doi: 10.1148/rycan.220127. Radiol Imaging Cancer. 2024. PMID: 38133553 Free PMC article.
-
The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis.Fac Rev. 2021 Jan 19;10:4. doi: 10.12703/r/10-4. eCollection 2021. Fac Rev. 2021. PMID: 33659922 Free PMC article. Review.
-
Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads.ACS Appl Mater Interfaces. 2022 Dec 14;14(49):54401-54410. doi: 10.1021/acsami.2c10493. Epub 2022 Nov 30. ACS Appl Mater Interfaces. 2022. PMID: 36448714 Free PMC article.
-
Chaperone-mediated autophagy promotes breast cancer angiogenesis via regulation of aerobic glycolysis.PLoS One. 2023 Mar 13;18(3):e0281577. doi: 10.1371/journal.pone.0281577. eCollection 2023. PLoS One. 2023. PMID: 36913368 Free PMC article.
-
The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters.Oncotarget. 2016 Apr 26;7(17):23141-55. doi: 10.18632/oncotarget.8153. Oncotarget. 2016. PMID: 27009812 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
