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Review
. 2000 Jul-Sep;17(7-9):485-99.
doi: 10.1023/a:1011062223612.

Achievements and challenges of sialic acid research

R Schauer  1
Affiliations
Review

Achievements and challenges of sialic acid research

R Schauer. Glycoconj J. 2000 Jul-Sep.

Abstract

Slalic acids are one of the most important molecules of life, since they occupy the terminal position on macromolecules and cell membranes and are involved in many biological and pathological phenomena. The structures of sialic acids, comprising a family of over 40 neuraminic acid derivatives, have been elucidated. However, many aspects of the regulation of their metabolism at the enzyme and gene levels, as well as of their functions remain mysterious. Sialic acids play a dual role, not only are they indispensable for the protection to and adaptation of life, but are also utilised by life-threatening infectious microorganisms. In this article the present state of knowledge in sialobiology, with an emphasis on my personal experience in this research area, is outlined including a discussion of necessary future work in this fascinating field of cell biology.

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References

    1. Gottschalk A, editor. The chemistry and biology of sialic acids and related substances. Cambridge: University Press; 1960.
    1. Blix G, Gottschalk A, Klenk E. Proposed nomenclature in the field of neuraminic and sialic acids. Nature. 1957;179:1088. - PubMed
    1. Faillard H, Schauer R. Glycoproteins as lubricants, protective agents, carriers, structural proteins and as participants in other functions. In: Gottschalk A, BBA Library 5, editor. Glycoproteins, Their Composition, Structure and Function. Amsterdam: Elsevier; 1972. pp. 1246–67.
    1. Klenk E. Neuraminsäure, das Spaltprodukt eines neuen Gehirn-lipoids. Hoppe-Seyler's Z Physiol Chem. 1941;268:50–8.
    1. Blix G. Ñber die Kohlenhydratgruppen des Submaxillarismucins. Hoppe-Seyler's Z Physiol Chem. 1936;240:43–54.

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