An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons
- PMID: 11420043
- DOI: 10.1016/s1074-7613(01)00152-2
An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons
Abstract
Interferon-alpha and -beta inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-beta-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.
Similar articles
-
IFN-zeta/ limitin: a member of type I IFN with mild lympho-myelosuppression.J Cell Mol Med. 2005 Apr-Jun;9(2):244-54. doi: 10.1111/j.1582-4934.2005.tb00353.x. J Cell Mol Med. 2005. PMID: 15963247 Free PMC article. Review.
-
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.Exp Hematol. 2003 Dec;31(12):1317-22. doi: 10.1016/j.exphem.2003.08.011. Exp Hematol. 2003. PMID: 14662340
-
Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.J Immunol. 2002 Nov 1;169(9):4707-11. doi: 10.4049/jimmunol.169.9.4707. J Immunol. 2002. PMID: 12391177
-
Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.FEBS Lett. 2003 Apr 10;540(1-3):223-8. doi: 10.1016/s0014-5793(03)00269-2. FEBS Lett. 2003. PMID: 12681512
-
The Daxx enigma.Apoptosis. 2000 Jun;5(3):217-20. doi: 10.1023/a:1009696227420. Apoptosis. 2000. PMID: 11225842 Review.
Cited by
-
Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.Front Immunol. 2024 Nov 4;15:1387229. doi: 10.3389/fimmu.2024.1387229. eCollection 2024. Front Immunol. 2024. PMID: 39559365 Free PMC article.
-
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4100-5. doi: 10.1073/pnas.0304768101. Epub 2004 Mar 11. Proc Natl Acad Sci U S A. 2004. PMID: 15016915 Free PMC article.
-
Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression.J Virol. 2006 Aug;80(16):8019-29. doi: 10.1128/JVI.02164-05. J Virol. 2006. PMID: 16873258 Free PMC article.
-
IFN-zeta/ limitin: a member of type I IFN with mild lympho-myelosuppression.J Cell Mol Med. 2005 Apr-Jun;9(2):244-54. doi: 10.1111/j.1582-4934.2005.tb00353.x. J Cell Mol Med. 2005. PMID: 15963247 Free PMC article. Review.
-
Innate immunity to adenovirus.Hum Gene Ther. 2014 Apr;25(4):265-84. doi: 10.1089/hum.2014.001. Epub 2014 Apr 8. Hum Gene Ther. 2014. PMID: 24512150 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
