Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma
- PMID: 11418003
- DOI: 10.1006/exmp.2001.2367
Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma
Abstract
Deregulated expression of inhibitors of apoptosis (programmed cell death) may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence of resistance to therapy. In this study, we investigated the potential expression and prognostic significance of the apoptosis inhibitor survivin in squamous cell carcinoma (SCC). A series of 135 cases of SCC including 46 oral SCC and 89 cutaneous SCC was analyzed for survivin expression by immunohistochemistry and Western blotting. Survivin was found in 57 cases (64%) of skin SCC and 26 cases (56%) of oral SCC, with weighted survivin scores ranging from 1 to 12. In contrast, normal oral epithelium, normal skin epithelium, and skin annexa did not express survivin. Survivin expression significantly (P < 0.05) segregated with high-grade and undifferentiated tumors with size >1.5 cm and invariably associated with lymph node metastasis. These data suggest that survivin expression may predictively identify cases of SCC with more aggressive and invasive clinical phenotype, potentially warranting closer follow-up protocols.
Copyright 2001 Academic Press.
Similar articles
-
Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan.Oral Oncol. 2005 Jul;41(6):645-54. doi: 10.1016/j.oraloncology.2005.02.009. Oral Oncol. 2005. PMID: 15927524
-
Stage and mRNA expression of survivin in lymph node as prognostic indicators in patients with oral squamous cell carcinoma.Cancer Lett. 2005 Jun 28;224(2):253-61. doi: 10.1016/j.canlet.2005.01.009. Cancer Lett. 2005. PMID: 15914276
-
Survivin as prognostic factor in squamous cell carcinoma of the oral cavity.Cancer Lett. 2005 Jul 8;225(1):27-33. doi: 10.1016/j.canlet.2004.11.024. Epub 2004 Dec 16. Cancer Lett. 2005. PMID: 15922854
-
Two different protein expression profiles of oral squamous cell carcinoma analyzed by immunoprecipitation high-performance liquid chromatography.World J Surg Oncol. 2017 Aug 8;15(1):151. doi: 10.1186/s12957-017-1213-5. World J Surg Oncol. 2017. PMID: 28789700 Free PMC article. Review.
-
Squamous Cell Carcinoma of the Lip-A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction.Dermatol Surg. 2017 Apr;43(4):494-506. doi: 10.1097/DSS.0000000000001020. Dermatol Surg. 2017. PMID: 28157733 Review.
Cited by
-
Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma.Br J Cancer. 2003 Jan 13;88(1):115-9. doi: 10.1038/sj.bjc.6600696. Br J Cancer. 2003. PMID: 12556969 Free PMC article.
-
The expression of survivin and Ki-67 in meningiomas: correlation with grade and clinical outcome.J Neurooncol. 2004 Mar-Apr;67(1-2):209-14. doi: 10.1023/b:neon.0000021823.05163.2c. J Neurooncol. 2004. PMID: 15072469
-
Survivin expression correlates with nodal metastasis in T1-T2 squamous cell carcinoma of the tongue.Eur Arch Otorhinolaryngol. 2015 Mar;272(3):689-94. doi: 10.1007/s00405-014-3009-3. Epub 2014 Mar 28. Eur Arch Otorhinolaryngol. 2015. PMID: 24676727
-
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?Cancer Med. 2016 Aug;5(8):2048-60. doi: 10.1002/cam4.731. Epub 2016 May 26. Cancer Med. 2016. PMID: 27228302 Free PMC article. Review.
-
Keratinocyte apoptosis in epidermal development and disease.J Invest Dermatol. 2006 Feb;126(2):243-57. doi: 10.1038/sj.jid.5700008. J Invest Dermatol. 2006. PMID: 16418733 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
