doi: 10.1016/s0925-4773(01)00367-7.
Smad5 is required for mouse primordial germ cell development
Affiliations
- PMID: 11404080
- DOI: 10.1016/s0925-4773(01)00367-7
Item in Clipboard
Smad5 is required for mouse primordial germ cell development
Mech Dev.
2001 Jun.
Free article
Abstract
Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined PGC number in Smad5 mutant mice by Oct4 whole-mount in situ hybridization and alkaline phosphatase staining. We found ectopic PGC-like cells in the amnion of some Smad5 mutant mice, however, the total number of PGCs was greatly reduced or completely absent in Smad5 mutant embryos, similar to Bmp4 or Bmp8b mutant embryos. Therefore, Smad5 is an important factor involved in PGC generation and localization.
Similar articles
-
Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.Development. 2006 Sep;133(17):3399-409. doi: 10.1242/dev.02497. Epub 2006 Aug 3. Development. 2006. PMID: 16887830
-
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.Mech Dev. 2002 Oct;118(1-2):99-109. doi: 10.1016/s0925-4773(02)00237-x. Mech Dev. 2002. PMID: 12351174
-
Mouse epiblasts change responsiveness to BMP4 signal required for PGC formation through functions of extraembryonic ectoderm.Mol Reprod Dev. 2005 Jan;70(1):20-9. doi: 10.1002/mrd.20136. Mol Reprod Dev. 2005. PMID: 15515057
-
The roles of BMPs, BMP antagonists, and the BMP signaling transducers Smad1 and Smad5 during dorsoventral patterning of the zebrafish embryo.Ernst Schering Res Found Workshop. 2000;(29):81-106. doi: 10.1007/978-3-662-04264-9_6. Ernst Schering Res Found Workshop. 2000. PMID: 10943306 Review. No abstract available.
-
[The role of Smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation].Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 Sep;17(5):359-62. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003. PMID: 14551929 Review. Chinese.
Cited by
-
Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.PLoS One. 2013;8(3):e57428. doi: 10.1371/journal.pone.0057428. Epub 2013 Mar 4. PLoS One. 2013. PMID: 23469192 Free PMC article.
-
Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.Dev Biol. 2006 Aug 1;296(1):104-18. doi: 10.1016/j.ydbio.2006.04.442. Dev Biol. 2006. PMID: 16765933 Free PMC article.
-
In Vitro Embryogenesis and Gastrulation Using Stem Cells in Mice and Humans.Int J Mol Sci. 2023 Sep 4;24(17):13655. doi: 10.3390/ijms241713655. Int J Mol Sci. 2023. PMID: 37686459 Free PMC article. Review.
-
Of Mice and Men: In Vivo and In Vitro Studies of Primordial Germ Cell Specification.Semin Reprod Med. 2017 Mar;35(2):139-146. doi: 10.1055/s-0037-1599085. Epub 2017 Mar 9. Semin Reprod Med. 2017. PMID: 28278531 Free PMC article. Review.
-
Spermatogonial stem cells specific marker identification in channel catfish, Ictalurus punctatus and blue catfish, I. furcatus.Fish Physiol Biochem. 2015 Dec;41(6):1545-56. doi: 10.1007/s10695-015-0106-1. Epub 2015 Aug 7. Fish Physiol Biochem. 2015. PMID: 26251285
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
