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. 2001 Jun 1;61(11):4315-9.

A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy

C W Gregory  1 , B He, R T Johnson, O H Ford, J L Mohler, F S French, E M Wilson
Affiliations
  • PMID: 11389051

A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy

C W Gregory et al. Cancer Res. .

Abstract

The development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors eventually recur and cause death. A critical question is whether the androgen receptor mediates recurrent tumor growth after androgen deprivation therapy. Here we report that a majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. Overexpression of these coactivators increases androgen receptor transactivation at physiological concentrations of adrenal androgen. Furthermore, we provide a molecular basis for this activation and suggest a general mechanism for recurrent prostate cancer growth.

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