Comparative Study
doi: 10.1016/s0960-894x(01)00259-1.
Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors
Affiliations
- PMID: 11378378
- DOI: 10.1016/s0960-894x(01)00259-1
Item in Clipboard
Comparative Study
Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors
Bioorg Med Chem Lett.
.
Abstract
A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer.
Similar articles
-
Synthesis and activity of selective MMP inhibitors with an aryl backbone.Bioorg Med Chem Lett. 2000 Dec 18;10(24):2815-7. doi: 10.1016/s0960-894x(00)00584-9. Bioorg Med Chem Lett. 2000. PMID: 11133099
-
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.Bioorg Med Chem Lett. 2003 Apr 17;13(8):1487-90. doi: 10.1016/s0960-894x(03)00127-6. Bioorg Med Chem Lett. 2003. PMID: 12668018
-
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.Bioorg Med Chem Lett. 1998 Oct 6;8(19):2657-62. doi: 10.1016/s0960-894x(98)00473-9. Bioorg Med Chem Lett. 1998. PMID: 9873598
-
Molecular diversity of hydroxamic acids: part II. Potential therapeutic applications.Mini Rev Med Chem. 2003 Sep;3(6):609-20. doi: 10.2174/1389557033487872. Mini Rev Med Chem. 2003. PMID: 12871163 Review.
-
Development of matrix metalloproteinase inhibitors in cancer therapy.J Natl Cancer Inst. 2001 Feb 7;93(3):178-93. doi: 10.1093/jnci/93.3.178. J Natl Cancer Inst. 2001. PMID: 11158186 Review.
Cited by
-
The ADAMTS metalloproteinases.Biochem J. 2005 Feb 15;386(Pt 1):15-27. doi: 10.1042/BJ20040424. Biochem J. 2005. PMID: 15554875 Free PMC article. Review.
-
L-selective amidase with extremely broad substrate specificity from Ochrobactrum anthropi NCIMB 40321.Appl Environ Microbiol. 2005 Dec;71(12):7961-73. doi: 10.1128/AEM.71.12.7961-7973.2005. Appl Environ Microbiol. 2005. PMID: 16332774 Free PMC article.
-
Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.Am J Respir Cell Mol Biol. 2015 Nov;53(5):585-600. doi: 10.1165/rcmb.2015-0020TR. Am J Respir Cell Mol Biol. 2015. PMID: 26121236 Free PMC article. Review.
-
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids.Tetrahedron Lett. 2013 Jun 19;54(25):3238-3240. doi: 10.1016/j.tetlet.2013.03.128. Tetrahedron Lett. 2013. PMID: 23794760 Free PMC article.
-
Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide.Cancer Sci. 2010 Mar;101(3):759-66. doi: 10.1111/j.1349-7006.2009.01435.x. Epub 2009 Nov 14. Cancer Sci. 2010. PMID: 20085585 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
