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Comment
. 2001 May 22;98(11):5949-51.
doi: 10.1073/pnas.111182398.

Factors affecting the developmental potential of cloned mammalian embryos

J C Cross  1
Affiliations
Comment

Factors affecting the developmental potential of cloned mammalian embryos

J C Cross. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Derivation and developmental potential of ES cell clones produced either by injection of ES cells into tetraploid blastocysts to produce chimeras or by transfer of ES cell nuclei into enucleated oocytes in mice. With both procedures, the manipulated embryos are cultured, and those that develop to the blastocyst stage are transferred to recipient females. The cumulative fraction of transferred blastocysts that result in adult mice is shown, based on the data from Eggan et al. (6). The fraction that develops from blastocyst to term gestation and from term gestation to adulthood is indicated in brackets. Tissues derived from the host embryo and ES cells are shown by blue and red, respectively. Note that in tetraploid chimeras, the placenta is mostly derived from the tetraploid cells, although the mesenchymal and vascular components are derived from the ES cells.
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