Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses
- PMID: 11358976
Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses
Abstract
Polymorphonuclear leukocytes (PMN) are the most abundant leukocytes, comprising about two-thirds of peripheral blood leukocytes, and play major roles in innate immunity. In addition, PMN play critical roles in the development of adaptive immunity. Recently, defensins and other peptides pre-stored in PMN granules were shown to attract monocytes, dendritic cells, and T cells, leading to the hypothesis that the release of PMN granular peptides may link innate and adaptive immunity. During the past several years, we have focused on an alternative hypothesis that activated PMN further differentiate and acquire new phenotypes and functions that enable them to link the two responses. To test our hypothesis, we have taken local and global approaches and have shown several key findings that support the hypothesis. The findings include the requirement for priming PMN by cytokines to induce the delayed expression of MCP-1/CCL2, a signal for mononuclear cells, and the expression of new cell-surface markers by such cytokine-activated PMN. In the present manuscript, we focus on the phenotypic and functional changes that occur during PMN activation with selected cytokines. The results of our study indicate that inflammatory PMN are heterogeneous and play roles in not only innate but also adaptive immunity in response to stimuli released in injured tissues.
Similar articles
-
Neutrophils induce the maturation of immature dendritic cells: a regulatory role of neutrophils in adaptive immune responses.Immunol Invest. 2007;36(3):337-50. doi: 10.1080/08820130601109719. Immunol Invest. 2007. PMID: 17558715
-
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators.Immunology. 2006 Nov;119(3):317-27. doi: 10.1111/j.1365-2567.2006.02435.x. Immunology. 2006. PMID: 17067311 Free PMC article.
-
Close encounters of neutrophils and DCs.Trends Immunol. 2005 Dec;26(12):626-31. doi: 10.1016/j.it.2005.09.007. Epub 2005 Sep 22. Trends Immunol. 2005. PMID: 16182604
-
Neutrophil granule proteins tune monocytic cell function.Trends Immunol. 2009 Nov;30(11):538-46. doi: 10.1016/j.it.2009.06.006. Epub 2009 Aug 21. Trends Immunol. 2009. PMID: 19699683 Review.
-
The impact of eicosanoids on the crosstalk between innate and adaptive immunity: the key roles of dendritic cells.Tissue Antigens. 2005 Jun;65(6):507-14. doi: 10.1111/j.1399-0039.2005.00394.x. Tissue Antigens. 2005. PMID: 15896197 Review.
Cited by
-
Rational design of hydrogels for immunomodulation.Regen Biomater. 2022 Feb 22;9:rbac009. doi: 10.1093/rb/rbac009. eCollection 2022. Regen Biomater. 2022. PMID: 35668923 Free PMC article. Review.
-
Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs.Front Immunol. 2024 Mar 26;15:1330373. doi: 10.3389/fimmu.2024.1330373. eCollection 2024. Front Immunol. 2024. PMID: 38596679 Free PMC article.
-
Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.J Biomed Biotechnol. 2012;2012:798924. doi: 10.1155/2012/798924. Epub 2012 May 10. J Biomed Biotechnol. 2012. PMID: 22654485 Free PMC article. Review.
-
New Insight on the Immune Modulation and Physical Barrier Protection Caused by Vitamin A in Fish Gills Infected With Flavobacterium columnare.Front Immunol. 2022 Mar 25;13:833455. doi: 10.3389/fimmu.2022.833455. eCollection 2022. Front Immunol. 2022. PMID: 35401542 Free PMC article.
-
Transplantation of Encapsulated Pancreatic Islets as a Treatment for Patients with Type 1 Diabetes Mellitus.Adv Med. 2014;2014:429710. doi: 10.1155/2014/429710. Epub 2014 Jan 30. Adv Med. 2014. PMID: 26556410 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous