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. 2001 Mar;51(3):172-8.
doi: 10.1046/j.1440-1827.2001.01182.x.

Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma

G Edakuni  1 , E Sasatomi, T Satoh, O Tokunaga, K Miyazaki
Affiliations

Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma

G Edakuni et al. Pathol Int. 2001 Mar.

Abstract

Expression of hepatocyte growth factor (HGF) and c-Met (HGF receptor) has been reported in many neoplasms. We investigated coexpression of HGF and c-Met to determine the role of the HGF/c-Met pathway in breast carcinoma, especially at the cancer front. Eighty-eight cases of carcinoma of the breast were studied by immunohistochemistry and by in situ hybridization for HGF and c-Met expression. The staining pattern was termed "front accentuation pattern" when it was most conspicuous at the cancer front. HGF and c-Met proteins were expressed in cancer and stromal cells, with autocrine and paracrine patterns. The front accentuation pattern of c-Met was observed in cancer cells, but not in stromal cells. The front accentuation pattern was not observed in HGF. Coexpression of HGF and c-Met at the cancer front was correlated with histologic grade, reduced patient survival and a high Ki-67 labeling index. Our findings suggest that the HGF/c-Met pathway acts primarily as a mitogen, especially at the cancer front, in a paracrine manner and affects some clinical factors, including patient survival.

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