Review
doi: 10.1038/35043058.
The many substrates and functions of ATM
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- PMID: 11252893
- DOI: 10.1038/35043058
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Review
The many substrates and functions of ATM
Nat Rev Mol Cell Biol.
2000 Dec.
Abstract
As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.
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