Interleukin-18 regulates both Th1 and Th2 responses
- PMID: 11244043
- DOI: 10.1146/annurev.immunol.19.1.423
Interleukin-18 regulates both Th1 and Th2 responses
Abstract
Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-1R/Toll-like receptor (TLR) superfamily, its function is quite different from that of IL-1. IL-18 is produced not only by types of immune cells but also by non-immune cells. In collaboration with IL-12, IL-18 stimulates Th1-mediated immune responses, which play a critical role in the host defense against infection with intracellular microbes through the induction of IFN-gamma. However, the overproduction of IL-12 and IL-18 induces severe inflammatory disorders, suggesting that IL-18 is a potent proinflammatory cytokine that has pathophysiological roles in several inflammatory conditions. IL-18 mRNA is expressed in a wide range of cells including Kupffer cells, macrophages, T cells, B cells, dendritic cells, osteoblasts, keratinocytes, astrocytes, and microglia. Thus, the pathophysiological role of IL-18 has been extensively tested in the organs that contain these cells. Somewhat surprisingly, IL-18 alone can stimulate Th2 cytokine production as well as allergic inflammation. Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12.
Similar articles
-
[Regulation of Th1 and Th2 immune responses by IL-18].Kekkaku. 2002 Feb;77(2):87-93. Kekkaku. 2002. PMID: 11905033 Review. Japanese.
-
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.Cytokine Growth Factor Rev. 2001 Mar;12(1):53-72. doi: 10.1016/s1359-6101(00)00015-0. Cytokine Growth Factor Rev. 2001. PMID: 11312119 Review.
-
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.J Immunol. 1998 Oct 1;161(7):3400-7. J Immunol. 1998. PMID: 9759857
-
Interleukin-18.Methods. 1999 Sep;19(1):121-32. doi: 10.1006/meth.1999.0837. Methods. 1999. PMID: 10525448 Review.
-
Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infection.Immunobiology. 2009;214(6):454-66. doi: 10.1016/j.imbio.2008.11.015. Epub 2009 Jan 19. Immunobiology. 2009. PMID: 19155092
Cited by
-
IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation.Sci Rep. 2016 Sep 21;6:33680. doi: 10.1038/srep33680. Sci Rep. 2016. PMID: 27649785 Free PMC article.
-
IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.Am J Respir Crit Care Med. 2012 Jun 1;185(11):1205-17. doi: 10.1164/rccm.201108-1545OC. Epub 2012 Mar 1. Am J Respir Crit Care Med. 2012. PMID: 22383501 Free PMC article.
-
NLRP3 Inflammasome and Pathobiology in AMD.J Clin Med. 2015 Jan 14;4(1):172-92. doi: 10.3390/jcm4010172. J Clin Med. 2015. PMID: 26237026 Free PMC article. Review.
-
MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection.Infect Immun. 2015 Apr;83(4):1265-75. doi: 10.1128/IAI.02619-14. Epub 2015 Jan 12. Infect Immun. 2015. PMID: 25583527 Free PMC article.
-
Interleukin-18 expression and the response to treatment in patients with psoriasis.Arch Med Sci. 2011 Aug;7(4):713-9. doi: 10.5114/aoms.2011.24144. Epub 2011 Sep 2. Arch Med Sci. 2011. PMID: 22291810 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
