doi: 10.1038/84769.
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
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- PMID: 11175780
- DOI: 10.1038/84769
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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Nat Genet.
2001 Feb.
Abstract
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.
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