Review
doi: 10.1016/s0959-440x(00)00144-5.
Floundering about at cell membranes: a structural view of phospholipid signaling
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- PMID: 11114512
- DOI: 10.1016/s0959-440x(00)00144-5
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Review
Floundering about at cell membranes: a structural view of phospholipid signaling
Curr Opin Struct Biol.
2000 Dec.
Abstract
Structures are now available for the majority of the enzyme families involved in the phosphorylation, dephosphorylation and hydrolysis of signaling phospholipids. Lipid kinase and phosphatase structures recapitulate catalytic motifs involved in protein phosphorylation and dephosphorylation, whereas cytosolic phospholipase A(2) manifests novel catalytic geometry. Structures have been determined for most known intracellular phospholipid 'receptor' domains, both those that bind membrane-embedded phospholipids and those that bind lipid monomers.
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