Review
doi: 10.1126/science.290.5497.1721.
How cells handle cholesterol
Affiliations
- PMID: 11099405
- DOI: 10.1126/science.290.5497.1721
Item in Clipboard
Review
How cells handle cholesterol
Science.
.
Abstract
Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Recent advances suggest that cholesterol exerts many of its actions mainly by maintaining sphingolipid rafts in a functional state. How rafts contribute to cholesterol metabolism and transport in the cell is still an open issue. It has long been known that cellular cholesterol levels are precisely controlled by biosynthesis, efflux from cells, and influx of lipoprotein cholesterol into cells. The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw light on diseases caused by cholesterol excess, the prime example being atherosclerosis.
Similar articles
-
Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking.Exp Biol Med (Maywood). 2001 Nov;226(10):873-90. doi: 10.1177/153537020122601002. Exp Biol Med (Maywood). 2001. PMID: 11682693 Review.
-
Cholesterol in the Cell Membrane-An Emerging Player in Atherogenesis.Int J Mol Sci. 2022 Jan 4;23(1):533. doi: 10.3390/ijms23010533. Int J Mol Sci. 2022. PMID: 35008955 Free PMC article. Review.
-
Intracellular cholesterol trafficking: role of the NPC1 protein.Biochim Biophys Acta. 2000 Jun 26;1486(1):171-83. doi: 10.1016/s1388-1981(00)00055-x. Biochim Biophys Acta. 2000. PMID: 10856720 Review. No abstract available.
-
The way we view cellular (glyco)sphingolipids.J Neurochem. 2007 Nov;103 Suppl 1:3-13. doi: 10.1111/j.1471-4159.2007.04721.x. J Neurochem. 2007. PMID: 17986134 Review.
-
Intra-Golgi protein transport depends on a cholesterol balance in the lipid membrane.J Biol Chem. 2003 Dec 26;278(52):53112-22. doi: 10.1074/jbc.M300402200. Epub 2003 Oct 14. J Biol Chem. 2003. PMID: 14561753
Cited by
-
Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4280-5. doi: 10.1073/pnas.1419799112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831522 Free PMC article.
-
Change of dynamics of raft-model membrane induced by amyloid-β protein binding.Eur Phys J E Soft Matter. 2013 Jul;36(7):74. doi: 10.1140/epje/i2013-13074-3. Epub 2013 Jul 16. Eur Phys J E Soft Matter. 2013. PMID: 23852578
-
Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer.Diabetes Care. 2013 Aug;36 Suppl 2(Suppl 2):S233-9. doi: 10.2337/dcS13-2001. Diabetes Care. 2013. PMID: 23882051 Free PMC article. Review. No abstract available.
-
Effect of ring-substituted oxysterols on the phase behavior of dipalmitoylphosphatidylcholine membranes.Eur Biophys J. 2012 Oct;41(10):891-900. doi: 10.1007/s00249-012-0823-7. Epub 2012 Jun 6. Eur Biophys J. 2012. PMID: 22669606
-
Lipid rafts: dream or reality for cholesterol transporters?Eur Biophys J. 2007 Nov;36(8):869-85. doi: 10.1007/s00249-007-0193-8. Epub 2007 Jun 19. Eur Biophys J. 2007. PMID: 17576551 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
