doi: 10.1126/science.290.5496.1594.
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
Affiliations
- PMID: 11090361
- DOI: 10.1126/science.290.5496.1594
Item in Clipboard
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
Science.
.
Abstract
Homologs of the Yersinia virulence effector YopJ are found in both plant and animal bacterial pathogens, as well as plant symbionts. These YopJ family members were shown to act as cysteine proteases. The catalytic triad of the protease was required for inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor kappaB (NF-kappaB) signaling in animal cells and for induction of localized cell death in plants. The substrates for YopJ were shown to be highly conserved ubiquitin-like molecules, which are covalently added to numerous regulatory proteins. YopJ family members exert their pathogenic effect on cells by disrupting this posttranslational modification.
Comment in
-
Microbiology. Unlocking the secrets of the grim reaper.Science. 2000 Nov 24;290(5496):1475. doi: 10.1126/science.290.5496.1475. Science. 2000. PMID: 11185496
Similar articles
-
Characterization of the Xanthomonas AvrXv4 effector, a SUMO protease translocated into plant cells.Mol Plant Microbe Interact. 2004 Jun;17(6):633-43. doi: 10.1094/MPMI.2004.17.6.633. Mol Plant Microbe Interact. 2004. PMID: 15195946
-
Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia.J Immunol. 2005 Jun 15;174(12):7939-49. doi: 10.4049/jimmunol.174.12.7939. J Immunol. 2005. PMID: 15944300
-
Function of the Yersinia effector YopJ.Curr Opin Microbiol. 2002 Feb;5(1):38-43. doi: 10.1016/s1369-5274(02)00283-7. Curr Opin Microbiol. 2002. PMID: 11834367 Review.
-
YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.Cell Microbiol. 2007 Nov;9(11):2700-15. doi: 10.1111/j.1462-5822.2007.00990.x. Epub 2007 Jun 30. Cell Microbiol. 2007. PMID: 17608743
-
Interference of eukaryotic signalling pathways by the bacteria Yersinia outer protein YopJ.Immunol Lett. 1999 Jun 1;68(2-3):199-203. doi: 10.1016/s0165-2478(99)00072-3. Immunol Lett. 1999. PMID: 10424421 Review.
Cited by
-
Deubiquitinating function of adenovirus proteinase.J Virol. 2002 Jun;76(12):6323-31. doi: 10.1128/jvi.76.12.6323-6331.2002. J Virol. 2002. PMID: 12021365 Free PMC article.
-
Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection.Infect Immun. 2002 Jul;70(7):3311-7. doi: 10.1128/IAI.70.7.3311-3317.2002. Infect Immun. 2002. PMID: 12065467 Free PMC article. Review. No abstract available.
-
Neutrophils are resistant to Yersinia YopJ/P-induced apoptosis and are protected from ROS-mediated cell death by the type III secretion system.PLoS One. 2010 Feb 18;5(2):e9279. doi: 10.1371/journal.pone.0009279. PLoS One. 2010. PMID: 20174624 Free PMC article.
-
A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates.Plant Cell. 2003 Oct;15(10):2308-19. doi: 10.1105/tpc.015487. Epub 2003 Sep 24. Plant Cell. 2003. PMID: 14507998 Free PMC article.
-
Haustorially expressed secreted proteins from flax rust are highly enriched for avirulence elicitors.Plant Cell. 2006 Jan;18(1):243-56. doi: 10.1105/tpc.105.035980. Epub 2005 Dec 2. Plant Cell. 2006. PMID: 16326930 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
