Review
doi: 10.1038/35041682.
Why do we age?
Affiliations
- PMID: 11089980
- DOI: 10.1038/35041682
Item in Clipboard
Review
Why do we age?
Nature.
.
Abstract
The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases.
Similar articles
-
Keynote lecture: an update on the what, why and how questions of ageing.Exp Gerontol. 2006 May;41(5):460-3. doi: 10.1016/j.exger.2006.03.009. Epub 2006 Apr 18. Exp Gerontol. 2006. PMID: 16621387 Review.
-
Understanding ageing.Philos Trans R Soc Lond B Biol Sci. 1997 Dec 29;352(1363):1793-7. doi: 10.1098/rstb.1997.0163. Philos Trans R Soc Lond B Biol Sci. 1997. PMID: 9460062 Free PMC article. Review.
-
Evolution of senescence: late survival sacrificed for reproduction.Philos Trans R Soc Lond B Biol Sci. 1991 Apr 29;332(1262):15-24. doi: 10.1098/rstb.1991.0028. Philos Trans R Soc Lond B Biol Sci. 1991. PMID: 1677205 Review.
-
[Extension of life: the apotheosis of the molecular biomedical sciences?].Tijdschr Gerontol Geriatr. 1990 Oct;21(5):199-204. Tijdschr Gerontol Geriatr. 1990. PMID: 2251720 Dutch.
-
Complex adaptive systems, aging and longevity.J Theor Biol. 2001 Dec 21;213(4):559-71. doi: 10.1006/jtbi.2001.2431. J Theor Biol. 2001. PMID: 11742525 Review.
Cited by
-
The ecology of ageing in wild societies: linking age structure and social behaviour.Philos Trans R Soc Lond B Biol Sci. 2024 Dec 16;379(1916):20220464. doi: 10.1098/rstb.2022.0464. Epub 2024 Oct 28. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 39463244 Free PMC article. Review.
-
Telomere- and oxidative stress dynamics in Psittacidae species with different longevity trajectories.Geroscience. 2024 Oct 25. doi: 10.1007/s11357-024-01397-5. Online ahead of print. Geroscience. 2024. PMID: 39448517
-
Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory.Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2408682121. doi: 10.1073/pnas.2408682121. Epub 2024 Oct 7. Proc Natl Acad Sci U S A. 2024. PMID: 39374394
-
Effects and Mechanisms of Lutein on Aging and Age-Related Diseases.Antioxidants (Basel). 2024 Sep 14;13(9):1114. doi: 10.3390/antiox13091114. Antioxidants (Basel). 2024. PMID: 39334773 Free PMC article. Review.
-
Fundamental equations linking methylation dynamics to maximum lifespan in mammals.Nat Commun. 2024 Sep 16;15(1):8093. doi: 10.1038/s41467-024-51855-z. Nat Commun. 2024. PMID: 39285199 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
