Epidemiologic studies on Dengue in Santiago de Cuba, 1997
- PMID: 11085389
- DOI: 10.1093/aje/152.9.793
Epidemiologic studies on Dengue in Santiago de Cuba, 1997
Abstract
A small, isolated outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) due to dengue virus type 2 (DEN-2) was documented in Santiago de Cuba on the island of Cuba beginning in January 1997. There were 205 DHF/DSS cases, all in persons older than age 15 years. All but three had evidence of a prior dengue infection, with the only known opportunity being the islandwide dengue virus type 1 (DEN-1) epidemic of 1977-1979. Virtually complete clinical and laboratory surveillance of overt disease was achieved. From December 1997 to January 1998, a random, age-stratified serum sample was obtained from 1,151 persons in 40 residential clusters in Santiago. Sera were tested for DEN-1 and DEN-2 neutralizing antibodies. The prevalence of DEN-2 antibodies in children age 15 years and under, born after the 1981 DEN-2 epidemic, was taken as the 1997 DEN-2 infection rate. This was adjusted slightly to accommodate observed cases, resulting in an estimated infection rate of 4.3%. Dengue fever and DHF/DSS attack rates were calculated from estimated total primary and secondary DEN-2 infections. Only 3% of 13,116 primary infections were overt. The DHF/DSS attack rate for adults of all ages was 420 per 10,000 secondary DEN-2 infections.
Comment in
-
Invited commentary: Dengue lessons from Cuba.Am J Epidemiol. 2000 Nov 1;152(9):800-3. doi: 10.1093/aje/152.9.800. Am J Epidemiol. 2000. PMID: 11085390 Review.
Similar articles
-
Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks.Rev Panam Salud Publica. 2002 Apr;11(4):223-7. doi: 10.1590/s1020-49892002000400003. Rev Panam Salud Publica. 2002. PMID: 12049030
-
Effect of age on outcome of secondary dengue 2 infections.Int J Infect Dis. 2002 Jun;6(2):118-24. doi: 10.1016/s1201-9712(02)90072-x. Int J Infect Dis. 2002. PMID: 12121599
-
Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study.Am J Trop Med Hyg. 1990 Feb;42(2):179-84. doi: 10.4269/ajtmh.1990.42.179. Am J Trop Med Hyg. 1990. PMID: 2316788
-
Invited commentary: Dengue lessons from Cuba.Am J Epidemiol. 2000 Nov 1;152(9):800-3. doi: 10.1093/aje/152.9.800. Am J Epidemiol. 2000. PMID: 11085390 Review.
-
Dengue: an update.Lancet Infect Dis. 2002 Jan;2(1):33-42. doi: 10.1016/s1473-3099(01)00171-2. Lancet Infect Dis. 2002. PMID: 11892494 Review.
Cited by
-
Estimating Dengue Transmission Intensity from Case-Notification Data from Multiple Countries.PLoS Negl Trop Dis. 2016 Jul 11;10(7):e0004833. doi: 10.1371/journal.pntd.0004833. eCollection 2016 Jul. PLoS Negl Trop Dis. 2016. PMID: 27399793 Free PMC article.
-
Variation in inflammatory/regulatory cytokines in secondary, tertiary, and quaternary challenges with dengue virus.Am J Trop Med Hyg. 2012 Sep;87(3):538-47. doi: 10.4269/ajtmh.2012.11-0531. Epub 2012 Jul 16. Am J Trop Med Hyg. 2012. PMID: 22802438 Free PMC article.
-
A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.PLoS Pathog. 2009 Dec;5(12):e1000695. doi: 10.1371/journal.ppat.1000695. Epub 2009 Dec 18. PLoS Pathog. 2009. PMID: 20019801 Free PMC article.
-
Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam.Sci Rep. 2019 Jun 28;9(1):9395. doi: 10.1038/s41598-019-45816-6. Sci Rep. 2019. PMID: 31253823 Free PMC article.
-
Dengue: a continuing global threat.Nat Rev Microbiol. 2010 Dec;8(12 Suppl):S7-16. doi: 10.1038/nrmicro2460. Nat Rev Microbiol. 2010. PMID: 21079655 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources