The evolutionary fate and consequences of duplicate genes
- PMID: 11073452
- DOI: 10.1126/science.290.5494.1151
The evolutionary fate and consequences of duplicate genes
Abstract
Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolve new functions. Observations from the genomic databases for several eukaryotic species suggest that duplicate genes arise at a very high rate, on average 0.01 per gene per million years. Most duplicated genes experience a brief period of relaxed selection early in their history, with a moderate fraction of them evolving in an effectively neutral manner during this period. However, the vast majority of gene duplicates are silenced within a few million years, with the few survivors subsequently experiencing strong purifying selection. Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species.
Comment in
-
Evolutionary biology. Twinned genes live life in the fast lane.Science. 2000 Nov 10;290(5494):1065-6. doi: 10.1126/science.290.5494.1065a. Science. 2000. PMID: 11184995
Comment on
-
Gene duplication and evolution.Science. 2001 Aug 31;293(5535):1551. doi: 10.1126/science.293.5535.1551a. Science. 2001. PMID: 11533445 No abstract available.
-
Gene duplication and evolution.Science. 2001 Aug 31;293(5535):1551. Science. 2001. PMID: 11550701 No abstract available.
Similar articles
-
The evolutionary demography of duplicate genes.J Struct Funct Genomics. 2003;3(1-4):35-44. J Struct Funct Genomics. 2003. PMID: 12836683 Review.
-
Gene duplication and evolution.Science. 2001 Aug 31;293(5535):1551. doi: 10.1126/science.293.5535.1551a. Science. 2001. PMID: 11533445 No abstract available.
-
Position-associated GC asymmetry of gene duplicates.J Mol Evol. 2004 Sep;59(3):372-84. doi: 10.1007/s00239-004-2631-x. J Mol Evol. 2004. PMID: 15553091
-
Birth and death of duplicated genes in completely sequenced eukaryotes.Trends Genet. 2001 May;17(5):237-9. doi: 10.1016/s0168-9525(01)02243-0. Trends Genet. 2001. PMID: 11335019 Review.
-
Preferential duplication of conserved proteins in eukaryotic genomes.PLoS Biol. 2004 Mar;2(3):E55. doi: 10.1371/journal.pbio.0020055. Epub 2004 Mar 16. PLoS Biol. 2004. PMID: 15024414 Free PMC article.
Cited by
-
The protein chaperone HSP90 can facilitate the divergence of gene duplicates.Genetics. 2013 Apr;193(4):1269-77. doi: 10.1534/genetics.112.148098. Epub 2013 Feb 14. Genetics. 2013. PMID: 23410833 Free PMC article.
-
New insights into siRNA amplification and RNAi.RNA Biol. 2012 Aug;9(8):1045-9. doi: 10.4161/rna.21246. Epub 2012 Aug 1. RNA Biol. 2012. PMID: 22858672 Free PMC article.
-
The influence of assortativity on the robustness and evolvability of gene regulatory networks upon gene birth.J Theor Biol. 2013 Aug 7;330:26-36. doi: 10.1016/j.jtbi.2013.03.019. Epub 2013 Mar 28. J Theor Biol. 2013. PMID: 23542384 Free PMC article.
-
Haplotype phasing and inheritance of copy number variants in nuclear families.PLoS One. 2015 Apr 8;10(4):e0122713. doi: 10.1371/journal.pone.0122713. eCollection 2015. PLoS One. 2015. PMID: 25853576 Free PMC article.
-
Reconstruction of cyclooxygenase evolution in animals suggests variable, lineage-specific duplications, and homologs with low sequence identity.J Mol Evol. 2015 Apr;80(3-4):193-208. doi: 10.1007/s00239-015-9670-3. Epub 2015 Mar 11. J Mol Evol. 2015. PMID: 25758350
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
