Review
doi: 10.1007/pl00000755.
Mechanisms of action of transcription activation and repression domains
Affiliations
- PMID: 11028908
- PMCID: PMC11147075
- DOI: 10.1007/pl00000755
Item in Clipboard
Review
Mechanisms of action of transcription activation and repression domains
Cell Mol Life Sci.
2000 Aug.
Abstract
Transcriptional regulators contain domains that either activate or repress transcription. Indeed, many cellular transcriptional regulators contain both activation and repression domains. Transcriptional regulators act at several stages in the transcription process, including assembly of the transcription complex, initiation and elongation. In order to influence these processes, the regulatory domains must interact with components of the transcription apparatus. This review will focus on our current understanding of the nature of transcriptional regulatory domains and their targets in the transcription machinery.
Similar articles
-
Large-scale mapping and mutagenesis of human transcriptional effector domains.Nature. 2023 Apr;616(7956):365-372. doi: 10.1038/s41586-023-05906-y. Epub 2023 Apr 5. Nature. 2023. PMID: 37020022 Free PMC article.
-
Signaling activation and repression of RNA polymerase II transcription in yeast.Bioessays. 1997 Nov;19(11):1001-10. doi: 10.1002/bies.950191110. Bioessays. 1997. PMID: 9394622 Review.
-
A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins.Mol Cell Biol. 1992 Dec;12(12):5508-15. doi: 10.1128/mcb.12.12.5508-5515.1992. Mol Cell Biol. 1992. PMID: 1448082 Free PMC article.
-
Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.Genetics. 2011 Nov;189(3):705-36. doi: 10.1534/genetics.111.127019. Genetics. 2011. PMID: 22084422 Free PMC article. Review.
-
[Regulation of gene expression and recent advance on transcription studies].Nihon Rinsho. 1995 Apr;53(4):1033-47. Nihon Rinsho. 1995. PMID: 7752463 Review. Japanese.
Cited by
-
Plant NAC-type transcription factor proteins contain a NARD domain for repression of transcriptional activation.Planta. 2010 Oct;232(5):1033-43. doi: 10.1007/s00425-010-1238-2. Epub 2010 Aug 4. Planta. 2010. PMID: 20683728
-
Plant class B HSFs inhibit transcription and exhibit affinity for TFIIB and TBP.Plant Mol Biol. 2004 Sep;56(1):57-75. doi: 10.1007/s11103-004-2307-3. Plant Mol Biol. 2004. PMID: 15604728
-
WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions.Protein J. 2018 Oct;37(5):391-406. doi: 10.1007/s10930-018-9785-7. Protein J. 2018. PMID: 30069656 Review.
-
Novel insights into the regulation of the timeless protein.J Neurosci. 2003 Aug 27;23(21):7810-9. doi: 10.1523/JNEUROSCI.23-21-07810.2003. J Neurosci. 2003. PMID: 12944510 Free PMC article.
-
Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications.Int J Mol Sci. 2020 Dec 21;21(24):9755. doi: 10.3390/ijms21249755. Int J Mol Sci. 2020. PMID: 33371315 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
