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. 2000 Oct 6;290(5489):134-8.
doi: 10.1126/science.290.5489.134.

Function of GATA transcription factors in preadipocyte-adipocyte transition

Q Tong  1 , G Dalgin, H Xu, C N Ting, J M Leiden, G S Hotamisligil
Affiliations

Function of GATA transcription factors in preadipocyte-adipocyte transition

Q Tong et al. Science. .

Abstract

Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in part, through the direct suppression of peroxisome proliferator-activated receptor gamma. GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition.

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