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. 2000 Sep 29;289(5488):2363-6.
doi: 10.1126/science.289.5488.2363.

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

D C Guttridge  1 , M W Mayo, L V Madrid, C Y Wang, A S Baldwin Jr
Affiliations

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

D C Guttridge et al. Science. .

Abstract

MyoD regulates skeletal muscle differentiation (SMD) and is essential for repair of damaged tissue. The transcription factor nuclear factor kappa B (NF-kappaB) is activated by the cytokine tumor necrosis factor (TNF), a mediator of skeletal muscle wasting in cachexia. Here, the role of NF-kappaB in cytokine-induced muscle degeneration was explored. In differentiating C2C12 myocytes, TNF-induced activation of NF-kappaB inhibited SMD by suppressing MyoD mRNA at the posttranscriptional level. In contrast, in differentiated myotubes, TNF plus interferon-gamma (IFN-gamma) signaling was required for NF-kappaB-dependent down-regulation of MyoD and dysfunction of skeletal myofibers. MyoD mRNA was also down-regulated by TNF and IFN-gamma expression in mouse muscle in vivo. These data elucidate a possible mechanism that may underlie the skeletal muscle decay in cachexia.

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