Review
doi: 10.1016/s0006-2952(00)00429-9.
Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
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- PMID: 11007962
- DOI: 10.1016/s0006-2952(00)00429-9
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Review
Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
Biochem Pharmacol.
.
Abstract
The purpose of this review is to summarize recent experimental data describing the regulation of the phosphorylation of eIF4E, the cap-binding protein, by the MAPK-activated protein kinase Mnk1. Mnk1 does not interact directly with eIF4E, but uses a docking site in eIF4G, a partner of eIF4E. Consequently, control of eIF4E phosphorylation may not strictly depend on changes in Mnk1 activity. The possibility that integrity of the eIF4E/eIF4G/Mnk1 complex also impinges upon eIF4E phosphorylation is discussed.
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