doi: 10.1016/s0006-8993(00)02707-4.
Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase
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- PMID: 10996156
- DOI: 10.1016/s0006-8993(00)02707-4
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Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase
Brain Res.
.
Abstract
We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration.
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