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Review
. 2000 Sep 4;150(5):F111-6.
doi: 10.1083/jcb.150.5.f111.

Molecular links between endocytosis and the actin cytoskeleton

B Qualmann  1 , M M Kessels, R B Kelly
Affiliations
Review

Molecular links between endocytosis and the actin cytoskeleton

B Qualmann et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Potential roles for the actin cytoskeleton in endocytosis. a–e, The model depicts how the cortical actin cytoskeleton might be involved in different steps of the endocytic process implicating potential functional roles for molecules at the interface of endocytosis and cytoskeletal organization. a, Cytoskeletal structures may organize or constrain the lateral mobility of the machinery for endocytosis. b, Deformation and invagination of the plasma membrane may be supported by the cytoskeleton. c, The cortical actin barrier underlying the plasma membrane might need to be dissolved. d, Actin polymerization may provide force to drive membrane fission during endocytic vesicle formation. e, Actin polymerization may promote the movement of newly formed endocytic vesicles into the cytoplasm by forming a comet tail. The remaining budding site may again be marked by proteins attached to cortical F-actin (a′) and endocytosis can start anew. f–h, Experimental data illustrating some of these hypothetical roles of actin in endocytosis. f, Highly organized endocytic hotspots marked by Dap160 (red) surrounded by sites of exocytosis (green, GluRB) at the Drosophila neuromuscular junction (image kindly provided by J. Roos). g, The cortical actin cytoskeleton and three different stages of clathrin-coated pit formation observed by quick freeze deep-etch EM (image kindly provided by J.E. Heuser). h, Electron micrograph of HeLa vesicle in Xenopus extracts exhibiting an actin tail and N-WASP immunolabeling at the vesicle surface (Taunton et al. 2000).
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