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. 2000 Jul;6(1):11-22.
doi: 10.1016/s1097-2765(00)00003-4.

Junctophilins: a novel family of junctional membrane complex proteins

H Takeshima  1 , S Komazaki, M Nishi, M Iino, K Kangawa
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Free article

Junctophilins: a novel family of junctional membrane complex proteins

H Takeshima et al. Mol Cell. 2000 Jul.
Free article

Abstract

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/ SR) are a common feature of all excitable cell types and mediate cross-talk between cell surface and intracellular ion channels. We have identified the junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. In mouse, there are at least three JP subtypes: JP-1, -2, and -3. JP-2 is abundantly expressed in the heart, and mutant mice lacking JP-2 exhibited embryonic lethality. Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes.

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