doi: 10.1016/s0304-3940(00)01334-3.
Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology
Affiliations
- PMID: 10936685
- DOI: 10.1016/s0304-3940(00)01334-3
Item in Clipboard
Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology
Neurosci Lett.
.
Abstract
To clarify (1) the localization of flotillins in human brain tissue and (2) the relationship between senile plaque formation and flotillins localization, we performed Western blotting and immunohistochemical analysis. Flotillins 1 and 2 were shown as 48 and 42 kDa bands, respectively, in human brain. The cerebral cortex showed a broad band-like labeling in entire layers. Flotillins were abundant in pyramidal neurons and astrocytes in the white matter. The intensity of the band-like labeling throughout the cortex became stronger with the development of senile plaque formation, and strongest in Alzheimer's disease. These findings suggest that flotillins are associated with progression of Alzheimer pathology.
Similar articles
-
Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease.Brain. 2014 Mar;137(Pt 3):887-903. doi: 10.1093/brain/awt362. Epub 2014 Feb 10. Brain. 2014. PMID: 24519982
-
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.Neurosci Lett. 2001 Jun 22;306(1-2):116-20. doi: 10.1016/s0304-3940(01)01876-6. Neurosci Lett. 2001. PMID: 11403971
-
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology.Brain Res. 2001 Sep 14;913(1):57-67. doi: 10.1016/s0006-8993(01)02758-5. Brain Res. 2001. PMID: 11532247
-
Comparison between Alzheimer's disease and vascular dementia: implications for treatment.Neurol Res. 2003 Sep;25(6):661-4. doi: 10.1179/016164103101201968. Neurol Res. 2003. PMID: 14503021 Review.
-
Beta-amyloid plaques: stages in life history or independent origin?Dement Geriatr Cogn Disord. 1998 Jul-Aug;9(4):227-38. doi: 10.1159/000017051. Dement Geriatr Cogn Disord. 1998. PMID: 9681645 Review.
Cited by
-
Alzheimer's disease beta-amyloid peptides are released in association with exosomes.Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7. doi: 10.1073/pnas.0603838103. Epub 2006 Jul 12. Proc Natl Acad Sci U S A. 2006. PMID: 16837572 Free PMC article.
-
Upregulation of endocytic protein expression in the Alzheimer's disease male human brain.Aging Brain. 2023 Jun 21;4:100084. doi: 10.1016/j.nbas.2023.100084. eCollection 2023. Aging Brain. 2023. PMID: 37449017 Free PMC article.
-
Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.Neurotox Res. 2004;6(4):245-57. doi: 10.1007/BF03033435. Neurotox Res. 2004. PMID: 15545008
-
Flotillin: A Promising Biomarker for Alzheimer's Disease.J Pers Med. 2020 Mar 26;10(2):20. doi: 10.3390/jpm10020020. J Pers Med. 2020. PMID: 32225073 Free PMC article. Review.
-
Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer's disease.Sci Adv. 2023 May 26;9(21):eade0293. doi: 10.1126/sciadv.ade0293. Epub 2023 May 26. Sci Adv. 2023. PMID: 37235655 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
