Review
doi: 10.1016/s0969-2126(00)00153-2.
Integrin-collagen complex: a metal-glutamate handshake
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- PMID: 10873865
- DOI: 10.1016/s0969-2126(00)00153-2
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Review
Integrin-collagen complex: a metal-glutamate handshake
Structure.
.
Free article
Abstract
The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.
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