Protein function in the post-genomic era
- PMID: 10866208
- DOI: 10.1038/35015694
Protein function in the post-genomic era
Abstract
Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of information but only flakes of knowledge. How can the thousands of sequences being determined and deposited, and the thousands of expression profiles being generated by the new array methods, be synthesized into useful knowledge? What form will this knowledge take? These are questions being addressed by scientists in the field known as 'functional genomics'.
Similar articles
-
[Prediction of functionally related proteins by comparative genomics in silico].Biomed Khim. 2009 May-Jun;55(3):230-46. Biomed Khim. 2009. PMID: 19662999 Review. Russian.
-
An Experimental Approach to Genome Annotation: This report is based on a colloquium sponsored by the American Academy of Microbiology held July 19-20, 2004, in Washington, DC.Washington (DC): American Society for Microbiology; 2004. Washington (DC): American Society for Microbiology; 2004. PMID: 33001599 Free Books & Documents. Review.
-
[Movements on the systems biology in the post-genome era: from genome, gene and protein analysis to biosystems analysis].Tanpakushitsu Kakusan Koso. 2002 Jul;47(9):1229-35. Tanpakushitsu Kakusan Koso. 2002. PMID: 12166069 Review. Japanese. No abstract available.
-
Computational genomics.Curr Biol. 2001 Mar 6;11(5):R155-8. doi: 10.1016/s0960-9822(01)00081-1. Curr Biol. 2001. PMID: 11267880
-
Protein function predictions based on the phylogenetic profile method.Crit Rev Biotechnol. 2008;28(4):233-8. doi: 10.1080/07388550802512633. Crit Rev Biotechnol. 2008. PMID: 19051102 Review.
Cited by
-
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks.BMC Bioinformatics. 2006 Jun 2;7:280. doi: 10.1186/1471-2105-7-280. BMC Bioinformatics. 2006. PMID: 16749936 Free PMC article.
-
Normalized L3-based link prediction in protein-protein interaction networks.BMC Bioinformatics. 2023 Feb 22;24(1):59. doi: 10.1186/s12859-023-05178-3. BMC Bioinformatics. 2023. PMID: 36814208 Free PMC article.
-
Domain fusion analysis by applying relational algebra to protein sequence and domain databases.BMC Bioinformatics. 2003 May 6;4:16. doi: 10.1186/1471-2105-4-16. Epub 2003 May 6. BMC Bioinformatics. 2003. PMID: 12734020 Free PMC article.
-
LOC3D: annotate sub-cellular localization for protein structures.Nucleic Acids Res. 2003 Jul 1;31(13):3337-40. doi: 10.1093/nar/gkg514. Nucleic Acids Res. 2003. PMID: 12824321 Free PMC article.
-
Bioinformatic analysis of the nucleolus.Biochem J. 2003 Dec 15;376(Pt 3):553-69. doi: 10.1042/BJ20031169. Biochem J. 2003. PMID: 14531731 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources