Review
doi: 10.1016/s0959-4388(00)00097-0.
Sequential steps in clathrin-mediated synaptic vesicle endocytosis
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- PMID: 10851177
- DOI: 10.1016/s0959-4388(00)00097-0
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Review
Sequential steps in clathrin-mediated synaptic vesicle endocytosis
Curr Opin Neurobiol.
2000 Jun.
Abstract
Synaptic vesicles are recycled with remarkable speed and precision in nerve terminals. A major recycling pathway involves clathrin-mediated endocytosis at endocytic zones located around sites of release. Different 'accessory' proteins linked to this pathway have been shown to alter the shape and composition of lipid membranes, to modify membrane-coat protein interactions, and to influence actin polymerization. These include the GTPase dynamin, the lysophosphatidic acid acyl transferase endophilin, and the phosphoinositide phosphatase synaptojanin. Protein perturbation studies in living nerve terminals are now beginning to link the actions of these proteins with morphologically defined steps of endocytosis.
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