Review
doi: 10.1038/sj.onc.1203481.
Serine phosphorylation of STATs
Affiliations
- PMID: 10851062
- DOI: 10.1038/sj.onc.1203481
Item in Clipboard
Review
Serine phosphorylation of STATs
Oncogene.
.
Abstract
Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite for the establishment of a classical JAK-STAT signaling path. However, most vertebrate STATs contain a second phosphorylation site within their C-termini. The phosphorylated residue in this case is a serine contained within a P(M)SP motif, and in the majority of situations its mutation to alanine alters transcription factor activity. This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process. The biochemical and biological consequences of STAT serine phosphorylation are discussed. Oncogene (2000).
Similar articles
-
STATs in oncogenesis.Oncogene. 2000 May 15;19(21):2474-88. doi: 10.1038/sj.onc.1203527. Oncogene. 2000. PMID: 10851046 Review.
-
Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.J Leukoc Biol. 2002 Oct;72(4):819-28. J Leukoc Biol. 2002. PMID: 12377952
-
STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.Cytokine Growth Factor Rev. 2004 Dec;15(6):435-55. doi: 10.1016/j.cytogfr.2004.09.001. Cytokine Growth Factor Rev. 2004. PMID: 15561601 Review.
-
Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3.Exp Cell Res. 2002 Jan 1;272(1):45-55. doi: 10.1006/excr.2001.5405. Exp Cell Res. 2002. PMID: 11740864
-
Cytoplasmic STAT proteins associate prior to activation.Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):417-21. Biochem J. 2000. PMID: 10642496 Free PMC article.
Cited by
-
LIF signal in mouse embryonic stem cells.JAKSTAT. 2015 Sep 11;4(2):e1086520. doi: 10.1080/21623996.2015.1086520. eCollection 2015. JAKSTAT. 2015. PMID: 27127728 Free PMC article. Review.
-
Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression.Oncotarget. 2015 Feb 10;6(4):1900-19. doi: 10.18632/oncotarget.2953. Oncotarget. 2015. PMID: 25595909 Free PMC article. Review.
-
IFNs-signaling effects on lung cancer: an up-to-date pathways-specific review.Clin Exp Med. 2017 Aug;17(3):281-289. doi: 10.1007/s10238-016-0432-3. Epub 2016 Jul 14. Clin Exp Med. 2017. PMID: 27416926 Review.
-
Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation.J Exp Med. 2002 Aug 5;196(3):311-21. doi: 10.1084/jem.20012041. J Exp Med. 2002. PMID: 12163560 Free PMC article.
-
IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.J Exp Clin Cancer Res. 2019 Sep 11;38(1):397. doi: 10.1186/s13046-019-1403-9. J Exp Clin Cancer Res. 2019. PMID: 31506076 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous
