Comparative Study
doi: 10.1038/75985.
Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
Affiliations
- PMID: 10835626
- DOI: 10.1038/75985
Item in Clipboard
Comparative Study
Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
Nat Genet.
2000 Jun.
Abstract
We show here that quantitative measurement of DNA copy number across amplified regions using array comparative genomic hybridization (CGH) may facilitate oncogene identification by providing precise information on the locations of both amplicon boundaries and amplification maxima. Using this analytical capability, we resolved two regions of amplification within an approximately 2-Mb region of recurrent aberration at 20q13.2 in breast cancer. The putative oncogene ZNF217 (ref. 5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other.
Similar articles
-
Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3.Cytogenet Cell Genet. 1993;62(4):192-3. doi: 10.1159/000133473. Cytogenet Cell Genet. 1993. PMID: 8440135 No abstract available.
-
Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization.J Pathol. 2003 Jul;200(3):320-6. doi: 10.1002/path.1359. J Pathol. 2003. PMID: 12845628
-
Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer.Ann Oncol. 2004 Feb;15(2):236-41. doi: 10.1093/annonc/mdh056. Ann Oncol. 2004. PMID: 14760115
-
The 17q23 amplicon and breast cancer.Breast Cancer Res Treat. 2003 Apr;78(3):313-22. doi: 10.1023/a:1023081624133. Breast Cancer Res Treat. 2003. PMID: 12755490 Review.
-
Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad.Biochim Biophys Acta. 2007 Jun;1775(2):333-40. doi: 10.1016/j.bbcan.2007.05.001. Epub 2007 May 22. Biochim Biophys Acta. 2007. PMID: 17572303 Review.
Cited by
-
Vitamin D: Current Challenges between the Laboratory and Clinical Practice.Nutrients. 2021 May 21;13(6):1758. doi: 10.3390/nu13061758. Nutrients. 2021. PMID: 34064098 Free PMC article. Review.
-
Inhibition of protein kinase CK2 reduces Cyp24a1 expression and enhances 1,25-dihydroxyvitamin D(3) antitumor activity in human prostate cancer cells.Cancer Res. 2013 Apr 1;73(7):2289-97. doi: 10.1158/0008-5472.CAN-12-4119. Epub 2013 Jan 28. Cancer Res. 2013. PMID: 23358686 Free PMC article.
-
aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL.Mutat Res. 2007 Feb 3;615(1-2):1-11. doi: 10.1016/j.mrfmmm.2006.09.006. Epub 2007 Jan 2. Mutat Res. 2007. PMID: 17196995 Free PMC article.
-
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.Endocr Rev. 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126. Endocr Rev. 2019. PMID: 30321335 Free PMC article. Review.
-
Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data.Nucleic Acids Res. 2008 Feb;36(2):e13. doi: 10.1093/nar/gkm1143. Epub 2008 Jan 10. Nucleic Acids Res. 2008. PMID: 18187509 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
etc
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
