Fc-receptors, Ia-antigens, and immunoglobulin on normal and activated mouse T lymphocytes
- PMID: 1081578
- PMCID: PMC2190069
- DOI: 10.1084/jem.142.6.1403
Fc-receptors, Ia-antigens, and immunoglobulin on normal and activated mouse T lymphocytes
Abstract
Using antibody coated bovine erythrocytes we were unable to demonstrate Fc-receptors on either thymus cells or T cells prepared from lymph node cell suspensions by anti-Ig column filtration. However, if parental thymus or lymph node T cells were transferred to X-irradiated F1 hybrids, activated donor T cells recovered from the recipient's spleen (ATC-spleen) were shown to express Fc-receptors. Fc-receptors were also demonstrable on ATC-spleen prepared between strain combinations differing at the M-locus. In marked contrast, Fc-receptors were not detected on ATC recovered from thoracic duct lymph (T.TDL). This applied to (a) H-2-activated T.TDL derived from normal thymus cells, (b) H-2-activated T.TDL derived from thymus cells depleted of B cells, and (c) M-locus-activated T.TDL. Of these three populations, surface Ig (of B cell origin) was detected on a large proportion of the first but not on the second and third populations. Thus, the failure to detect Fc-receptors on any of these populations could not be attributed to blocking by adsorbed surface Ig. In addition, various T-cell populations were examined by a microcytotoxicity assay for the presence of cell surface Ia-antigens. 5--10% of the thymus cells, 20--30% of cortisone-resistant thymus cells, 60--70% of lymph node cells, and 60--80% of ATC-spleen and T.TDL showed Ia.
Similar articles
-
A subpopulation of T cells bearing Fc receptors.J Immunol. 1975 Oct;115(4):1159-65. J Immunol. 1975. PMID: 1100723
-
The origin of cell surface immunoglobulin of marrow-derived and thymus-derived lymphocytes of the rat.J Exp Med. 1974 Mar 1;139(3):479-96. doi: 10.1084/jem.139.3.479. J Exp Med. 1974. PMID: 4544247 Free PMC article.
-
Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components.J Exp Med. 1975 May 1;141(5):1201-9. doi: 10.1084/jem.141.5.1201. J Exp Med. 1975. PMID: 1079233 Free PMC article.
-
Human lymphocyte subpopulations: classification according to surface markers and-or functional characteristics.Transplant Rev. 1973;16:163-95. doi: 10.1111/j.1600-065x.1973.tb00120.x. Transplant Rev. 1973. PMID: 4272900 Review. No abstract available.
-
Antibody-dependent cell-mediated cytolysis (ADCC): analyses and projections.Prog Allergy. 1977;22:1-44. Prog Allergy. 1977. PMID: 325576 Review. No abstract available.
Cited by
-
Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes.J Exp Med. 1976 Feb 1;143(2):444-9. doi: 10.1084/jem.143.2.444. J Exp Med. 1976. PMID: 55453 Free PMC article.
-
Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.Am J Pathol. 1979 Oct;97(1):149-206. Am J Pathol. 1979. PMID: 495693 Free PMC article.
-
Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice.Proc Natl Acad Sci U S A. 1979 Jan;76(1):457-61. doi: 10.1073/pnas.76.1.457. Proc Natl Acad Sci U S A. 1979. PMID: 311474 Free PMC article.
-
Mast cell membrane antigens and Fc receptors in anaphylaxis. I. Products of the major histocompatibility complex involved in alloantibody-induced mast cell activation.Immunology. 1979 Nov;38(3):447-58. Immunology. 1979. PMID: 521051 Free PMC article.
-
Regulatory mechanisms in cell-mediated immune responses. VIII. Differential expression of I-region determinants by suppressor cells and their targets in suppression of mixed leukocyte reactions.J Exp Med. 1979 Nov 1;150(5):1108-21. doi: 10.1084/jem.150.5.1108. J Exp Med. 1979. PMID: 91654 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
