Brain tumor invasion rate measured in vitro does not correlate with Ki-67 expression
- PMID: 10778726
- DOI: 10.1023/a:1006375316331
Brain tumor invasion rate measured in vitro does not correlate with Ki-67 expression
Abstract
The need for more accurate prediction of the biological behavior of brain tumors has lead to the use of immunohistochemical methods for assessment of proliferating cell nuclear antigens such as Ki-67. There is a variable association of glioma Ki-67 labeling index with patient survival. Brain invasion by individual tumor cells also defines biological aggressiveness, and can be assessed in vitro. Further, proliferation and migration seem to be mutually exclusive behaviors for a given cell at a point in time. We studied the relationship between Ki-67 labeling index and invasion rate in a group of 10 gliomas, and 2 meningiomas. Human tumor spheroids obtained from operative specimen were co-cultured with fetal rat brain aggregates, and invasion rate was measured by confocal microscopic observation. There was no correlation between two measures of invasion and Ki-67 labeling. This finding supports the dichotomous nature of glioma proliferation and invasion, and may in part explain the limited usefulness of proliferation marker labeling.
Similar articles
-
PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade.J Neurooncol. 2002 Apr;57(2):115-21. doi: 10.1023/a:1015739130208. J Neurooncol. 2002. PMID: 12125971
-
Dynamic determination of human glioma invasion in vitro.J Neurosurg. 1998 Sep;89(3):441-7. doi: 10.3171/jns.1998.89.3.0441. J Neurosurg. 1998. PMID: 9724119
-
Progression of astrocytomas and meningiomas: an evaluation in vitro.Cell Prolif. 2007 Feb;40(1):14-23. doi: 10.1111/j.1365-2184.2007.00415.x. Cell Prolif. 2007. PMID: 17227292 Free PMC article.
-
[Use of tumor proliferation marker ki-67 and PCNA in surgical pathology].Zhonghua Bing Li Xue Za Zhi. 2009 Aug;38(8):568-71. Zhonghua Bing Li Xue Za Zhi. 2009. PMID: 20021977 Review. Chinese. No abstract available.
-
Pathologic analysis of primary brain tumors.Neurol Clin. 1985 Nov;3(4):711-28. Neurol Clin. 1985. PMID: 3001488 Review.
Cited by
-
Systematic review of protein biomarkers of invasive behavior in glioblastoma.Mol Neurobiol. 2014 Jun;49(3):1212-44. doi: 10.1007/s12035-013-8593-5. Epub 2013 Nov 24. Mol Neurobiol. 2014. PMID: 24271659 Review.
-
The integrated brain network that controls respiration.Elife. 2023 Mar 8;12:e83654. doi: 10.7554/eLife.83654. Elife. 2023. PMID: 36884287 Free PMC article. Review.
-
Computer simulation of glioma growth and morphology.Neuroimage. 2007;37 Suppl 1(Suppl 1):S59-70. doi: 10.1016/j.neuroimage.2007.03.008. Epub 2007 Mar 23. Neuroimage. 2007. PMID: 17475515 Free PMC article.
-
Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression.Neuro Oncol. 2023 Dec 8;25(12):2150-2162. doi: 10.1093/neuonc/noad109. Neuro Oncol. 2023. PMID: 37335907 Free PMC article.
-
Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.Am J Pathol. 2003 May;162(5):1549-57. doi: 10.1016/S0002-9440(10)64289-7. Am J Pathol. 2003. PMID: 12707039 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical