A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta
- PMID: 10769382
- DOI: 10.1038/74805
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta
Abstract
Voltage-gated sodium channels in brain neurons were found to associate with receptor protein tyrosine phosphatase beta (RPTPbeta) and its catalytically inactive, secreted isoform phosphacan, and this interaction was regulated during development. Both the extracellular domain and the intracellular catalytic domain of RPTPbeta interacted with sodium channels. Sodium channels were tyrosine phosphorylated and were modulated by the associated catalytic domains of RPTPbeta. Dephosphorylation slowed sodium channel inactivation, positively shifted its voltage dependence, and increased whole-cell sodium current. Our results define a sodium channel signaling complex containing RPTPbeta, which acts to regulate sodium channel modulation by tyrosine phosphorylation.
Comment in
-
Sodium channels develop a tyrosine phosphatase complex.Nat Neurosci. 2000 May;3(5):417-9. doi: 10.1038/74777. Nat Neurosci. 2000. PMID: 10769374 No abstract available.
Similar articles
-
Sodium channels develop a tyrosine phosphatase complex.Nat Neurosci. 2000 May;3(5):417-9. doi: 10.1038/74777. Nat Neurosci. 2000. PMID: 10769374 No abstract available.
-
Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta.Biochem Biophys Res Commun. 2005 Sep 16;335(1):232-9. doi: 10.1016/j.bbrc.2005.07.060. Biochem Biophys Res Commun. 2005. PMID: 16105548
-
Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan.Neuroscience. 2005;131(2):331-48. doi: 10.1016/j.neuroscience.2004.11.017. Neuroscience. 2005. PMID: 15708477
-
[Neural proteoglycans: neuroglycan C (NGC), neurocan, and phosphacan].Tanpakushitsu Kakusan Koso. 1997 Feb;42(3 Suppl):567-70. Tanpakushitsu Kakusan Koso. 1997. PMID: 9162999 Review. Japanese. No abstract available.
-
DSD-1-Proteoglycan/Phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues.Adv Exp Med Biol. 2006;557:25-53. doi: 10.1007/0-387-30128-3_3. Adv Exp Med Biol. 2006. PMID: 16955703 Review.
Cited by
-
Sites and molecular mechanisms of modulation of Na(v)1.2 channels by Fyn tyrosine kinase.J Neurosci. 2007 Oct 24;27(43):11543-51. doi: 10.1523/JNEUROSCI.1743-07.2007. J Neurosci. 2007. PMID: 17959797 Free PMC article.
-
Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.J Neurosci. 2010 Feb 24;30(8):3113-23. doi: 10.1523/JNEUROSCI.5598-09.2010. J Neurosci. 2010. PMID: 20181608 Free PMC article.
-
Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets.Expert Opin Ther Targets. 2008 Sep;12(9):1191-203. doi: 10.1517/14728222.12.9.1191. Expert Opin Ther Targets. 2008. PMID: 18694383 Free PMC article.
-
Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease.Neuropharmacology. 2018 Apr;132:43-57. doi: 10.1016/j.neuropharm.2017.09.018. Epub 2017 Sep 18. Neuropharmacology. 2018. PMID: 28927993 Free PMC article. Review.
-
Channel activation voltage alone is directly altered in an isoform-specific manner by Na(v1.4) and Na(v1.5) cytoplasmic linkers.J Membr Biol. 2004 Feb 1;197(3):155-68. doi: 10.1007/s00232-004-0650-6. J Membr Biol. 2004. PMID: 15042347
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
